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Understanding human gut diseases at single-cell resolution
Our understanding of gut functioning and pathophysiology has grown considerably in the past decades, and advancing technologies enable us to deepen this understanding. Single-cell RNA sequencing (scRNA-seq) has opened a new realm of cellular diversity and transcriptional variation in the human gut a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530522/ https://www.ncbi.nlm.nih.gov/pubmed/32588873 http://dx.doi.org/10.1093/hmg/ddaa130 |
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author | Bigaeva, Emilia Uniken Venema, Werna T C Weersma, Rinse K Festen, Eleonora A M |
author_facet | Bigaeva, Emilia Uniken Venema, Werna T C Weersma, Rinse K Festen, Eleonora A M |
author_sort | Bigaeva, Emilia |
collection | PubMed |
description | Our understanding of gut functioning and pathophysiology has grown considerably in the past decades, and advancing technologies enable us to deepen this understanding. Single-cell RNA sequencing (scRNA-seq) has opened a new realm of cellular diversity and transcriptional variation in the human gut at a high, single-cell resolution. ScRNA-seq has pushed the science of the digestive system forward by characterizing the function of distinct cell types within complex intestinal cellular environments, by illuminating the heterogeneity within specific cell populations and by identifying novel cell types in the human gut that could contribute to a variety of intestinal diseases. In this review, we highlight recent discoveries made with scRNA-seq that significantly advance our understanding of the human gut both in health and across the spectrum of gut diseases, including inflammatory bowel disease, colorectal carcinoma and celiac disease. |
format | Online Article Text |
id | pubmed-7530522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75305222020-10-07 Understanding human gut diseases at single-cell resolution Bigaeva, Emilia Uniken Venema, Werna T C Weersma, Rinse K Festen, Eleonora A M Hum Mol Genet Invited Review Article Our understanding of gut functioning and pathophysiology has grown considerably in the past decades, and advancing technologies enable us to deepen this understanding. Single-cell RNA sequencing (scRNA-seq) has opened a new realm of cellular diversity and transcriptional variation in the human gut at a high, single-cell resolution. ScRNA-seq has pushed the science of the digestive system forward by characterizing the function of distinct cell types within complex intestinal cellular environments, by illuminating the heterogeneity within specific cell populations and by identifying novel cell types in the human gut that could contribute to a variety of intestinal diseases. In this review, we highlight recent discoveries made with scRNA-seq that significantly advance our understanding of the human gut both in health and across the spectrum of gut diseases, including inflammatory bowel disease, colorectal carcinoma and celiac disease. Oxford University Press 2020-06-26 /pmc/articles/PMC7530522/ /pubmed/32588873 http://dx.doi.org/10.1093/hmg/ddaa130 Text en © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Article Bigaeva, Emilia Uniken Venema, Werna T C Weersma, Rinse K Festen, Eleonora A M Understanding human gut diseases at single-cell resolution |
title | Understanding human gut diseases at single-cell resolution |
title_full | Understanding human gut diseases at single-cell resolution |
title_fullStr | Understanding human gut diseases at single-cell resolution |
title_full_unstemmed | Understanding human gut diseases at single-cell resolution |
title_short | Understanding human gut diseases at single-cell resolution |
title_sort | understanding human gut diseases at single-cell resolution |
topic | Invited Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530522/ https://www.ncbi.nlm.nih.gov/pubmed/32588873 http://dx.doi.org/10.1093/hmg/ddaa130 |
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