Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models

Amyotrophic lateral sclerosis (ALS) is an incurable neurological disease with progressive loss of motor neuron (MN) function in the brain and spinal cord. Mutations in TARDBP, encoding the RNA-binding protein TDP-43, are one cause of ALS, and TDP-43 mislocalization in MNs is a key pathological featu...

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Detalles Bibliográficos
Autores principales: Marques, Rita F, Engler, Jan B, Küchler, Katrin, Jones, Ross A, Lingner, Thomas, Salinas, Gabriela, Gillingwater, Thomas H, Friese, Manuel A, Duncan, Kent E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530531/
https://www.ncbi.nlm.nih.gov/pubmed/32686835
http://dx.doi.org/10.1093/hmg/ddaa140

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