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Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression

The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by sev...

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Autores principales: Grau-Bové, Xavier, Tomlinson, Sean, O’Reilly, Andrias O, Harding, Nicholas J, Miles, Alistair, Kwiatkowski, Dominic, Donnelly, Martin J, Weetman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530614/
https://www.ncbi.nlm.nih.gov/pubmed/32449755
http://dx.doi.org/10.1093/molbev/msaa128
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author Grau-Bové, Xavier
Tomlinson, Sean
O’Reilly, Andrias O
Harding, Nicholas J
Miles, Alistair
Kwiatkowski, Dominic
Donnelly, Martin J
Weetman, David
author_facet Grau-Bové, Xavier
Tomlinson, Sean
O’Reilly, Andrias O
Harding, Nicholas J
Miles, Alistair
Kwiatkowski, Dominic
Donnelly, Martin J
Weetman, David
author_sort Grau-Bové, Xavier
collection PubMed
description The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across nonconcordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticide-based intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors.
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spelling pubmed-75306142020-10-07 Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression Grau-Bové, Xavier Tomlinson, Sean O’Reilly, Andrias O Harding, Nicholas J Miles, Alistair Kwiatkowski, Dominic Donnelly, Martin J Weetman, David Mol Biol Evol Discoveries The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin locus (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across nonconcordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticide-based intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors. Oxford University Press 2020-05-21 /pmc/articles/PMC7530614/ /pubmed/32449755 http://dx.doi.org/10.1093/molbev/msaa128 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discoveries
Grau-Bové, Xavier
Tomlinson, Sean
O’Reilly, Andrias O
Harding, Nicholas J
Miles, Alistair
Kwiatkowski, Dominic
Donnelly, Martin J
Weetman, David
Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression
title Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression
title_full Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression
title_fullStr Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression
title_full_unstemmed Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression
title_short Evolution of the Insecticide Target Rdl in African Anopheles Is Driven by Interspecific and Interkaryotypic Introgression
title_sort evolution of the insecticide target rdl in african anopheles is driven by interspecific and interkaryotypic introgression
topic Discoveries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530614/
https://www.ncbi.nlm.nih.gov/pubmed/32449755
http://dx.doi.org/10.1093/molbev/msaa128
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