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Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
Macrophages play a central role in dictating the tissue response to infection and orchestrating subsequent repair of the damage. In this context, macrophages residing in the lungs continuously sense and discriminate among a wide range of insults to initiate the immune responses important to host-def...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530636/ https://www.ncbi.nlm.nih.gov/pubmed/33072072 http://dx.doi.org/10.3389/fimmu.2020.02091 |
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author | Rayees, Sheikh Rochford, Ian Joshi, Jagdish Chandra Joshi, Bhagwati Banerjee, Somenath Mehta, Dolly |
author_facet | Rayees, Sheikh Rochford, Ian Joshi, Jagdish Chandra Joshi, Bhagwati Banerjee, Somenath Mehta, Dolly |
author_sort | Rayees, Sheikh |
collection | PubMed |
description | Macrophages play a central role in dictating the tissue response to infection and orchestrating subsequent repair of the damage. In this context, macrophages residing in the lungs continuously sense and discriminate among a wide range of insults to initiate the immune responses important to host-defense. Inflammatory tissue injury also leads to activation of proteases, and thereby the coagulation pathway, to optimize injury and repair post-infection. However, long-lasting inflammatory triggers from macrophages can impair the lung's ability to recover from severe injury, leading to increased lung vascular permeability and neutrophilic injury, hallmarks of Acute Lung Injury (ALI). In this review, we discuss the roles of toll-like receptor 4 (TLR4) and protease activating receptor 2 (PAR2) expressed on the macrophage cell-surface in regulating lung vascular inflammatory signaling. |
format | Online Article Text |
id | pubmed-7530636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75306362020-10-17 Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair Rayees, Sheikh Rochford, Ian Joshi, Jagdish Chandra Joshi, Bhagwati Banerjee, Somenath Mehta, Dolly Front Immunol Immunology Macrophages play a central role in dictating the tissue response to infection and orchestrating subsequent repair of the damage. In this context, macrophages residing in the lungs continuously sense and discriminate among a wide range of insults to initiate the immune responses important to host-defense. Inflammatory tissue injury also leads to activation of proteases, and thereby the coagulation pathway, to optimize injury and repair post-infection. However, long-lasting inflammatory triggers from macrophages can impair the lung's ability to recover from severe injury, leading to increased lung vascular permeability and neutrophilic injury, hallmarks of Acute Lung Injury (ALI). In this review, we discuss the roles of toll-like receptor 4 (TLR4) and protease activating receptor 2 (PAR2) expressed on the macrophage cell-surface in regulating lung vascular inflammatory signaling. Frontiers Media S.A. 2020-09-18 /pmc/articles/PMC7530636/ /pubmed/33072072 http://dx.doi.org/10.3389/fimmu.2020.02091 Text en Copyright © 2020 Rayees, Rochford, Joshi, Joshi, Banerjee and Mehta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Rayees, Sheikh Rochford, Ian Joshi, Jagdish Chandra Joshi, Bhagwati Banerjee, Somenath Mehta, Dolly Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair |
title | Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair |
title_full | Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair |
title_fullStr | Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair |
title_full_unstemmed | Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair |
title_short | Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair |
title_sort | macrophage tlr4 and par2 signaling: role in regulating vascular inflammatory injury and repair |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530636/ https://www.ncbi.nlm.nih.gov/pubmed/33072072 http://dx.doi.org/10.3389/fimmu.2020.02091 |
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