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Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair

Macrophages play a central role in dictating the tissue response to infection and orchestrating subsequent repair of the damage. In this context, macrophages residing in the lungs continuously sense and discriminate among a wide range of insults to initiate the immune responses important to host-def...

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Autores principales: Rayees, Sheikh, Rochford, Ian, Joshi, Jagdish Chandra, Joshi, Bhagwati, Banerjee, Somenath, Mehta, Dolly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530636/
https://www.ncbi.nlm.nih.gov/pubmed/33072072
http://dx.doi.org/10.3389/fimmu.2020.02091
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author Rayees, Sheikh
Rochford, Ian
Joshi, Jagdish Chandra
Joshi, Bhagwati
Banerjee, Somenath
Mehta, Dolly
author_facet Rayees, Sheikh
Rochford, Ian
Joshi, Jagdish Chandra
Joshi, Bhagwati
Banerjee, Somenath
Mehta, Dolly
author_sort Rayees, Sheikh
collection PubMed
description Macrophages play a central role in dictating the tissue response to infection and orchestrating subsequent repair of the damage. In this context, macrophages residing in the lungs continuously sense and discriminate among a wide range of insults to initiate the immune responses important to host-defense. Inflammatory tissue injury also leads to activation of proteases, and thereby the coagulation pathway, to optimize injury and repair post-infection. However, long-lasting inflammatory triggers from macrophages can impair the lung's ability to recover from severe injury, leading to increased lung vascular permeability and neutrophilic injury, hallmarks of Acute Lung Injury (ALI). In this review, we discuss the roles of toll-like receptor 4 (TLR4) and protease activating receptor 2 (PAR2) expressed on the macrophage cell-surface in regulating lung vascular inflammatory signaling.
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spelling pubmed-75306362020-10-17 Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair Rayees, Sheikh Rochford, Ian Joshi, Jagdish Chandra Joshi, Bhagwati Banerjee, Somenath Mehta, Dolly Front Immunol Immunology Macrophages play a central role in dictating the tissue response to infection and orchestrating subsequent repair of the damage. In this context, macrophages residing in the lungs continuously sense and discriminate among a wide range of insults to initiate the immune responses important to host-defense. Inflammatory tissue injury also leads to activation of proteases, and thereby the coagulation pathway, to optimize injury and repair post-infection. However, long-lasting inflammatory triggers from macrophages can impair the lung's ability to recover from severe injury, leading to increased lung vascular permeability and neutrophilic injury, hallmarks of Acute Lung Injury (ALI). In this review, we discuss the roles of toll-like receptor 4 (TLR4) and protease activating receptor 2 (PAR2) expressed on the macrophage cell-surface in regulating lung vascular inflammatory signaling. Frontiers Media S.A. 2020-09-18 /pmc/articles/PMC7530636/ /pubmed/33072072 http://dx.doi.org/10.3389/fimmu.2020.02091 Text en Copyright © 2020 Rayees, Rochford, Joshi, Joshi, Banerjee and Mehta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Rayees, Sheikh
Rochford, Ian
Joshi, Jagdish Chandra
Joshi, Bhagwati
Banerjee, Somenath
Mehta, Dolly
Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
title Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
title_full Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
title_fullStr Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
title_full_unstemmed Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
title_short Macrophage TLR4 and PAR2 Signaling: Role in Regulating Vascular Inflammatory Injury and Repair
title_sort macrophage tlr4 and par2 signaling: role in regulating vascular inflammatory injury and repair
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530636/
https://www.ncbi.nlm.nih.gov/pubmed/33072072
http://dx.doi.org/10.3389/fimmu.2020.02091
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