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High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma

Background: Studies have shown mitochondrial genome content (mtDNA content) varies in many malignancies. However, its distribution and prognostic values in high-grade meningioma remain largely unknown. In this retrospective study, we sought to assess a putative correlation between the mtDNA content...

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Autores principales: Hua, Lingyang, Juratli, Tareq A., Zhu, Hongda, Deng, Jiaojiao, Wang, Daijun, Sun, Shuchen, Xie, Qing, Wakimoto, Hiroaki, Gong, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530740/
https://www.ncbi.nlm.nih.gov/pubmed/33072573
http://dx.doi.org/10.3389/fonc.2020.542294
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author Hua, Lingyang
Juratli, Tareq A.
Zhu, Hongda
Deng, Jiaojiao
Wang, Daijun
Sun, Shuchen
Xie, Qing
Wakimoto, Hiroaki
Gong, Ye
author_facet Hua, Lingyang
Juratli, Tareq A.
Zhu, Hongda
Deng, Jiaojiao
Wang, Daijun
Sun, Shuchen
Xie, Qing
Wakimoto, Hiroaki
Gong, Ye
author_sort Hua, Lingyang
collection PubMed
description Background: Studies have shown mitochondrial genome content (mtDNA content) varies in many malignancies. However, its distribution and prognostic values in high-grade meningioma remain largely unknown. In this retrospective study, we sought to assess a putative correlation between the mtDNA content and clinical characteristics. Methods: Mitochondrial DNA was extracted from 87 World Health Organization grade III meningioma samples using a qPCR method. The distribution of mtDNA content in WHO grade III meningioma and its correlations with clinical variables were assessed. Furthermore, we prognostic values were also determined. Results: Mean mtDNA content was 617.7 (range, 0.8–3000). There was no mtDNA distribution difference based on the histological subtypes (P = 0.07). Tumors with preoperative radiation were associated with lower mtDNA content (P = 0.041), whereas no correlations with other clinical variables were observed. A high mtDNA content was associated with significantly better PFS (P = 0.044) and OS (P = 0.019). However, in patients who received postoperative radiotherapy, low mtDNA content was associated with better PFS (P = 0.028), while no difference in OS was observed (P = 0.272). Low mtDNA content was also associated with better OS and PFS in subgroups of patients with ER negative status (PFS, P = 0.002; OS, P = 0.002). Conclusions: Consistent with other tumors, high mtDNA content was associated with better outcome in WHO grade III meningioma in our cohort. However, for patients who received post-operative radiation therapy, low mtDNA content was associated with better PFS. These findings suggest that mtDNA content may further be explored as a potential biomarker for high-grade meningioma patients and for those who received postoperative radiation therapy.
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spelling pubmed-75307402020-10-17 High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma Hua, Lingyang Juratli, Tareq A. Zhu, Hongda Deng, Jiaojiao Wang, Daijun Sun, Shuchen Xie, Qing Wakimoto, Hiroaki Gong, Ye Front Oncol Oncology Background: Studies have shown mitochondrial genome content (mtDNA content) varies in many malignancies. However, its distribution and prognostic values in high-grade meningioma remain largely unknown. In this retrospective study, we sought to assess a putative correlation between the mtDNA content and clinical characteristics. Methods: Mitochondrial DNA was extracted from 87 World Health Organization grade III meningioma samples using a qPCR method. The distribution of mtDNA content in WHO grade III meningioma and its correlations with clinical variables were assessed. Furthermore, we prognostic values were also determined. Results: Mean mtDNA content was 617.7 (range, 0.8–3000). There was no mtDNA distribution difference based on the histological subtypes (P = 0.07). Tumors with preoperative radiation were associated with lower mtDNA content (P = 0.041), whereas no correlations with other clinical variables were observed. A high mtDNA content was associated with significantly better PFS (P = 0.044) and OS (P = 0.019). However, in patients who received postoperative radiotherapy, low mtDNA content was associated with better PFS (P = 0.028), while no difference in OS was observed (P = 0.272). Low mtDNA content was also associated with better OS and PFS in subgroups of patients with ER negative status (PFS, P = 0.002; OS, P = 0.002). Conclusions: Consistent with other tumors, high mtDNA content was associated with better outcome in WHO grade III meningioma in our cohort. However, for patients who received post-operative radiation therapy, low mtDNA content was associated with better PFS. These findings suggest that mtDNA content may further be explored as a potential biomarker for high-grade meningioma patients and for those who received postoperative radiation therapy. Frontiers Media S.A. 2020-09-18 /pmc/articles/PMC7530740/ /pubmed/33072573 http://dx.doi.org/10.3389/fonc.2020.542294 Text en Copyright © 2020 Hua, Juratli, Zhu, Deng, Wang, Sun, Xie, Wakimoto and Gong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Hua, Lingyang
Juratli, Tareq A.
Zhu, Hongda
Deng, Jiaojiao
Wang, Daijun
Sun, Shuchen
Xie, Qing
Wakimoto, Hiroaki
Gong, Ye
High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma
title High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma
title_full High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma
title_fullStr High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma
title_full_unstemmed High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma
title_short High Tumor Mitochondrial DNA Content Correlates With an Improved Patient's Outcome in WHO Grade III Meningioma
title_sort high tumor mitochondrial dna content correlates with an improved patient's outcome in who grade iii meningioma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530740/
https://www.ncbi.nlm.nih.gov/pubmed/33072573
http://dx.doi.org/10.3389/fonc.2020.542294
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