Cargando…

ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis

Liver tests (LT), especially to measure AST, ALT and GGT levels, are widely used to evaluate the risk of alcohol-related liver disease (ALD). In this study, we investigated the potential genetic factors that modulate the association between LTs and alcohol consumption. We conducted a genome-wide int...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sutoh, Yoichi, Hachiya, Tsuyoshi, Suzuki, Yuji, Komaki, Shohei, Ohmomo, Hideki, Kakisaka, Keisuke, Wang, Ting, Takikawa, Yasuhiro, Shimizu, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530747/ https://www.ncbi.nlm.nih.gov/pubmed/33004991 http://dx.doi.org/10.1038/s41598-020-73263-1

Ejemplares similares

Evaluation of clinical formalin‐fixed paraffin‐embedded tissue quality for targeted‐bisulfite sequencing
por: Ohmomo, Hideki, et al.
Publicado: (2020)

DNA Methylation Abnormalities and Altered Whole Transcriptome Profiles after Switching from Combustible Tobacco Smoking to Heated Tobacco Products
por: Ohmomo, Hideki, et al.
Publicado: (2022)

Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics
por: Komaki, Shohei, et al.
Publicado: (2021)

Integrated analysis of human DNA methylation, gene expression, and genomic variation in iMETHYL database using kernel tensor decomposition-based unsupervised feature extraction
por: Taguchi, Y-h., et al.
Publicado: (2023)

Evaluation of short-term epigenetic age fluctuation
por: Komaki, Shohei, et al.
Publicado: (2022)

Genome-wide analysis of polymorphism × sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus
por: Hachiya, Tsuyoshi, et al.
Publicado: (2018)

Evaluation of De Ritis (AST/ALT), ALP/ALT, and AST/ALP ratios as prognostic factors in patients with acute ischemic stroke
por: Ahmadabad, Mona Asghari, et al.
Publicado: (2022)

Genome-wide meta-analysis in Japanese populations identifies novel variants at the TMC6–TMC8 and SIX3–SIX2 loci associated with HbA(1c)
por: Hachiya, Tsuyoshi, et al.
Publicado: (2017)

iMETHYL: an integrative database of human DNA methylation, gene expression, and genomic variation
por: Komaki, Shohei, et al.
Publicado: (2018)

Liver Enzymes: Interaction Analysis of Smoking with Alcohol Consumption or BMI, Comparing AST and ALT to γ-GT
por: Breitling, Lutz P., et al.
Publicado: (2011)

Ribavirin: Mild elevation of bilirubin and AST/ALT: case report
Publicado: (2016)

The significance of transaminase ratio (AST/ALT) in acute myocardial infarction
por: Djakpo, Dodji Kossi, et al.
Publicado: (2020)

AST-to-ALT ratio in the first trimester and the risk of gestational diabetes mellitus
por: An, Rongjing, et al.
Publicado: (2022)

Acute liver failure precipitated by acute Budd‐Chiari syndrome and complete portal vein thrombosis
por: Suzuki, Yuji, et al.
Publicado: (2021)

Reference Intervals of Total Bilirubin, ALT, AST, and Creatinine in Healthy Elderly Chinese
por: Zhang, Guo-ming, et al.
Publicado: (2014)

Aspartate Aminotransferase (AST/GOT) and Alanine Aminotransferase (ALT/GPT) Detection Techniques
por: Huang, Xing-Jiu, et al.
Publicado: (2006)

Can elevated concentrations of ALT and AST predict the risk of ‘recurrence’ of COVID-19?
por: Chen, L. Z., et al.
Publicado: (2020)

AST/ALT ratio as a significant predictor of the incidence risk of prostate cancer
por: Zhou, Jiatong, et al.
Publicado: (2020)

An updated meta-analysis of AST and ALT levels and the mortality of COVID-19 patients
por: Wang, Ying, et al.
Publicado: (2021)

Elevated AST/ALT ratio is associated with all‐cause mortality and cancer incident
por: Chen, Wangyang, et al.
Publicado: (2022)

Prognostic Value of the AST/ALT Ratio versus Bilirubin in Patients with Cardiogenic Shock
por: Schupp, Tobias, et al.
Publicado: (2023)

Splenic infarction associated with acute infectious mononucleosis
por: Suzuki, Yuji, et al.
Publicado: (2018)

Obstructive Bezoars of the Small Bowel Treated with Coca-Cola Zero through a Long Intestinal Tube and Endoscopic Manipulation
por: Endo, Kei, et al.
Publicado: (2017)

Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma
por: Kakisaka, Keisuke, et al.
Publicado: (2021)

The prognostic significance of serum gamma-glutamyltransferase levels and AST/ALT in primary hepatic carcinoma
por: Zhang, Li-xiang, et al.
Publicado: (2019)

The AST/ALT (De Ritis) Ratio Predicts Survival in Patients with Oral and Oropharyngeal Cancer
por: Knittelfelder, Olivia, et al.
Publicado: (2020)

Tocilizumab: Elevated AST and ALT following off label therapy: 11 case reports
Publicado: (2021)

The association between AST/ALT ratio and all-cause and cardiovascular mortality in patients with hypertension
por: Liu, Hui, et al.
Publicado: (2021)

Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus
por: Ma, Wenjie, et al.
Publicado: (2022)

High AST/ALT Ratio Is Associated with Cardiac Involvement in Acute COVID-19 Patients
por: Karatas, Mesut, et al.
Publicado: (2023)

AST and ALT APRI Scores and Dysglycemia in Saudi Arabia: A Retrospective Population Study
por: Alshuweishi, Yazeed, et al.
Publicado: (2023)

Hepatitis B Surface Antibody Titers at One and Two Years after Hepatitis B Virus Vaccination in Healthy Young Japanese Adults
por: Kakisaka, Keisuke, et al.
Publicado: (2019)

AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study
por: Liu, Yongmei, et al.
Publicado: (2018)

Incremental Predictive Value of Serum AST-to-ALT Ratio for Incident Metabolic Syndrome: The ARIRANG Study
por: Yadav, Dhananjay, et al.
Publicado: (2016)

Remdesivir: Elevated AST and ALT levels following off-label therapy: 4 case reports
Publicado: (2020)

The Prognosis Role of AST/ALT (De Ritis) Ratio in Patients with Adult Secondary Hemophagocytic Lymphohistiocytosis
por: Yin, Guangli, et al.
Publicado: (2020)

ALT/AST as an Independent Risk Factor of Gestational Diabetes Mellitus Compared with TG/HDL-C
por: Song, Shuoning, et al.
Publicado: (2022)

Aptasensors Are Conjectured as Promising ALT and AST Diagnostic Tools for the Early Diagnosis of Acute Liver Injury
por: Chinnappan, Raja, et al.
Publicado: (2023)

Association of serum brain-derived neurotrophic factor with hepatic enzymes, AST/ALT ratio, and FIB-4 index in middle-aged and older women
por: Yokokawa, Takumi, et al.
Publicado: (2022)

De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke
por: Gao, Fan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ck7b1euvjh9or40d6nqjqnrud9