M. tuberculosis class II apurinic/ apyrimidinic‐endonuclease/3′‐5′ exonuclease (XthA) engages with NAD(+)-dependent DNA ligase A (LigA) to counter futile cleavage and ligation cycles in base excision repair

Class-II AP-endonuclease (XthA) and NAD(+)-dependent DNA ligase (LigA) are involved in initial and terminal stages of bacterial DNA base excision repair (BER), respectively. XthA acts on abasic sites of damaged DNA to create nicks with 3′OH and 5′-deoxyribose phosphate (5′-dRP) moieties. Co-immunopr...

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Detalles Bibliográficos
Autores principales: Khanam, Taran, Afsar, Mohammad, Shukla, Ankita, Alam, Faiyaz, Kumar, Sanjay, Soyar, Horam, Dolma, Kunzes, , Ashish, Pasupuleti, Mukesh, Srivastava, Kishore Kumar, Ampapathi, Ravi Sankar, Ramachandran, Ravishankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530888/
https://www.ncbi.nlm.nih.gov/pubmed/32232338
http://dx.doi.org/10.1093/nar/gkaa188

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