Cargando…

Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry

BACKGROUND: Proctitis is an inflammation of the rectum and may be induced by radiation treatment for cancer. The genetic heritability of developing radiotoxicity and prior role of genetic variants as being associated with side-effects of radiotherapy necessitates further investigation for underlying...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pathak, Gita A., Polimanti, Renato, Silzer, Talisa K., Wendt, Frank R., Chakraborty, Ranajit, Phillips, Nicole R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530964/ https://www.ncbi.nlm.nih.gov/pubmed/33008348 http://dx.doi.org/10.1186/s12885-020-07457-1

Ejemplares similares

Mitochondrial tRNA methylation in Alzheimer’s disease and progressive supranuclear palsy
por: Silzer, Talisa K., et al.
Publicado: (2020)

Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent
por: De Lillo, Antonella, et al.
Publicado: (2023)

Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes
por: Wendt, Frank R., et al.
Publicado: (2022)

Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent
por: Wendt, Frank R, et al.
Publicado: (2021)

Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans
por: Silzer, Talisa, et al.
Publicado: (2019)

Differentiation of Hispanic biogeographic ancestry with 80 ancestry informative markers
por: Setser, Casandra H., et al.
Publicado: (2020)

Copy number variation signature to predict human ancestry
por: Pronold, Melissa, et al.
Publicado: (2012)

Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective
por: Wendt, Frank R., et al.
Publicado: (2020)

Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort
por: Wendt, Frank R., et al.
Publicado: (2020)

ACE2 Netlas: In-silico functional characterization and drug-gene interactions of ACE2 gene network to understand its potential involvement in COVID-19 susceptibility
por: Pathak, Gita A, et al.
Publicado: (2020)

Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders
por: Wendt, Frank R, et al.
Publicado: (2019)

PHENOME-WIDE GENETIC CORRELATION AND CAUSALITY OF COVID-19 SEVERITY HIGHLIGHTS OVERLAP WITH SUBSTANCE-USE TRAITS
por: Pathak, Gita, et al.
Publicado: (2021)

Rare copy number variants in over 100,000 European ancestry subjects reveal multiple disease associations
por: Li, Yun Rose, et al.
Publicado: (2020)

Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry
por: Albawardi, Alia, et al.
Publicado: (2021)

Multivariate genome-wide analysis of education, socioeconomic status, and brain phenome
por: Wendt, Frank R., et al.
Publicado: (2020)

ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility
por: Pathak, Gita A., et al.
Publicado: (2021)

Phlegmonous Proctitis: A Rare Entity of the Presentation of Proctitis
por: Kaewdech, Apichat, et al.
Publicado: (2018)

Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program
por: Wendt, Frank R., et al.
Publicado: (2023)

Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk
por: De Angelis, Flavio, et al.
Publicado: (2021)

The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort
por: Zaidi, Arslan A., et al.
Publicado: (2023)

The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study
por: Cabrera-Mendoza, Brenda, et al.
Publicado: (2022)

Neonatal Variables, Altitude of Residence and Aymara Ancestry in Northern Chile
por: Rothhammer, Francisco, et al.
Publicado: (2015)

Copy Number Variation across European Populations
por: Chen, Wanting, et al.
Publicado: (2011)

Patient genetics is linked to chronic wound microbiome composition and healing
por: Tipton, Craig D., et al.
Publicado: (2020)

Extensive Copy Number Variations in Admixed Indian Population of African Ancestry: Potential Involvement in Adaptation
por: Narang, Ankita, et al.
Publicado: (2014)

A Curious Case of Severe Proctitis
por: Lopez, Christine R., et al.
Publicado: (2023)

Management of radiation-induced proctitis
por: Porouhan, Pejman, et al.
Publicado: (2019)

Radiation Proctitis and Management Strategies
por: Dahiya, Dushyant Singh, et al.
Publicado: (2022)

Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations
por: Koller, Dora, et al.
Publicado: (2022)

Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders
por: Koller, Dora, et al.
Publicado: (2023)

Hypermethylation at CREBBP Is Associated with Cognitive Impairment in a Mexican American Cohort
por: Abraham Daniel, Ann, et al.
Publicado: (2023)

Adaptation dynamics between copy-number and point mutations
por: Tomanek, Isabella, et al.
Publicado: (2022)

Copy Number Heterogeneity of JC Virus Standards
por: Greninger, Alexander L., et al.
Publicado: (2017)

Diclofenac suppositories and acute ischaemic proctitis.
por: Arya, N., et al.
Publicado: (2004)

Radiation Proctitis: Current Strategies in Management
por: Do, Nhue L., et al.
Publicado: (2011)

Sexually transmitted infections manifesting as proctitis
por: Lamb, Chris A, et al.
Publicado: (2013)

Perianal Abscess and Proctitis by Klebsiella pneumoniae
por: Jeong, Woo Shin, et al.
Publicado: (2015)

Secondary Amyloidosis Presenting as Ischemic Proctitis
por: Hashmi, Saad, et al.
Publicado: (2021)

Severe Mpox Proctitis Complicated by Bowel Obstruction
por: Saleh, Hasan, et al.
Publicado: (2023)

Simple water‐based tacrolimus enemas for refractory proctitis
por: Fehily, Sasha R., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_shpc88ditsvabgiui967r887c5