Cargando…

Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

Gramicidin A (1) is a peptide antibiotic that disrupts the transmembrane ion concentration gradient by forming an ion channel in a lipid bilayer. Although long used clinically, it is limited to topical application because of its strong hemolytic activity and mammalian cytotoxicity, likely arising fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takada, Yuri, Itoh, Hiroaki, Paudel, Atmika, Panthee, Suresh, Hamamoto, Hiroshi, Sekimizu, Kazuhisa, Inoue, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531004/ https://www.ncbi.nlm.nih.gov/pubmed/33004797 http://dx.doi.org/10.1038/s41467-020-18711-2

Ejemplares similares

Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E
por: Itoh, Hiroaki, et al.
Publicado: (2019)

Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents
por: Panthee, Suresh, et al.
Publicado: (2017)

Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b
por: Panthee, Suresh, et al.
Publicado: (2017)

GPI0363 inhibits the interaction of RNA polymerase with DNA in Staphylococcus aureus
por: Paudel, Atmika, et al.
Publicado: (2019)

Complete Genome Sequence of Weissella hellenica 0916-4-2 and Its Comparative Genomic Analysis
por: Panthee, Suresh, et al.
Publicado: (2019)

Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model
por: Panthee, Suresh, et al.
Publicado: (2021)

YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus
por: Paudel, Atmika, et al.
Publicado: (2021)

Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 1768
por: Panthee, Suresh, et al.
Publicado: (2018)

The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus
por: Panthee, Suresh, et al.
Publicado: (2020)

Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus
por: Hamamoto, Hiroshi, et al.
Publicado: (2021)

Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model
por: Paudel, Atmika, et al.
Publicado: (2018)

Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220
por: Panthee, Suresh, et al.
Publicado: (2022)

Transcriptome change of Staphylococcus aureus in infected mouse liver
por: Hamamoto, Hiroshi, et al.
Publicado: (2022)

A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus
por: Paudel, Atmika, et al.
Publicado: (2017)

Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth
por: Xue, Yun-Wei, et al.
Publicado: (2022)

Synthesis, Screening, and Sequencing of Cysteine-Rich One-Bead One-Compound Peptide Libraries
por: Juskowiak, Gary L., et al.
Publicado: (2008)

Rapid Lead Discovery Through Iterative Screening of One Bead One Compound Libraries
por: Gao, Yu, et al.
Publicado: (2014)

Rapid discovery of self-assembling peptides with one-bead one-compound peptide library
por: Yang, Pei-Pei, et al.
Publicado: (2021)

N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler
por: Sorochkina, Alexandra I., et al.
Publicado: (2012)

Artificial Gramicidins
por: Sun, Zhanhu, et al.
Publicado: (2019)

A One-Dimensional Continuum Elastic Model for Membrane-Embedded Gramicidin Dimer Dissociation
por: Stember, Joseph N., et al.
Publicado: (2011)

Comparative analysis of COVID‐19 case fatality rate between two waves in Nepal
por: GC, Sulochan, et al.
Publicado: (2021)

One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer
por: Yang, Fan, et al.
Publicado: (2019)

Tandem Gramicidin Channels Cross-linked by Streptavidin
por: Rokitskaya, Tatyana I., et al.
Publicado: (2003)

A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen
por: Roof, Rebecca A, et al.
Publicado: (2009)

Multiplexed Competitive Screening of One-Bead-One-Component Combinatorial Libraries Using a ClonePix 2 Colony Sorter
por: Lavoie, R. Ashton, et al.
Publicado: (2019)

Enhanced Eryptosis Following Gramicidin Exposure
por: Malik, Abaid, et al.
Publicado: (2015)

Atomistic Characterization of Gramicidin Channel Formation
por: Sun, Delin, et al.
Publicado: (2020)

Structure, toxicity and antibiotic activity of gramicidin S and derivatives
por: Swierstra, J., et al.
Publicado: (2016)

Establishment of a Bacterial Infection Model Using the European Honeybee, Apis mellifera L
por: Ishii, Kenichi, et al.
Publicado: (2014)

Pharmacokinetics of anti-infectious reagents in silkworms
por: Hamamoto, Hiroshi, et al.
Publicado: (2019)

Exploration of the One-Bead One-Compound Methodology for the Design of Prolyl Oligopeptidase Substrates
por: Comellas, Gemma, et al.
Publicado: (2009)

Therapeutic Potential of Gramicidin S in the Treatment of Root Canal Infections
por: Berditsch, Marina, et al.
Publicado: (2016)

Gramicidin A: A New Mission for an Old Antibiotic
por: David, Justin M., et al.
Publicado: (2015)

The Iterative Gramicidin S Thioesterase Catalyzes Peptide Ligation and Cyclization
por: Hoyer, Katharina M., et al.
Publicado: (2007)

The effect of gramicidin inclusions on the local order of membrane components
por: Azar, Elise, et al.
Publicado: (2018)

Effects of Calcium Ions on the Antimicrobial Activity of Gramicidin A
por: Fang, Shang-Ting, et al.
Publicado: (2022)

Managing the one-person library
por: Cooperman, Larry
Publicado: (2015)

Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources
por: Asami, Yukihiro, et al.
Publicado: (2010)

In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms
por: Anantaworasakul, Pimporn, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7htk4bg591jeua8l9v2ljf7jol