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Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library

Gramicidin A (1) is a peptide antibiotic that disrupts the transmembrane ion concentration gradient by forming an ion channel in a lipid bilayer. Although long used clinically, it is limited to topical application because of its strong hemolytic activity and mammalian cytotoxicity, likely arising fr...

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Detalles Bibliográficos
Autores principales:	Takada, Yuri, Itoh, Hiroaki, Paudel, Atmika, Panthee, Suresh, Hamamoto, Hiroshi, Sekimizu, Kazuhisa, Inoue, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531004/ https://www.ncbi.nlm.nih.gov/pubmed/33004797 http://dx.doi.org/10.1038/s41467-020-18711-2

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