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The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer
Over the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. C...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531035/ https://www.ncbi.nlm.nih.gov/pubmed/33072064 http://dx.doi.org/10.3389/fimmu.2020.01721 |
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author | Qiao, Xin-wei Jiang, Jian Pang, Xin Huang, Mei-chang Tang, Ya-jie Liang, Xin-hua Tang, Ya-ling |
author_facet | Qiao, Xin-wei Jiang, Jian Pang, Xin Huang, Mei-chang Tang, Ya-jie Liang, Xin-hua Tang, Ya-ling |
author_sort | Qiao, Xin-wei |
collection | PubMed |
description | Over the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. Compared with traditional therapies, the emerging PD-1/PD-L1 blockade immunotherapy exhibited more satisfactory curative effects and lower toxicity for patients with advanced head and neck squamous cell carcinoma (HNSCC). This review analyzes the expression characteristics and clinical significance of PD-1/PD-L1 in HNSCC, the immunosuppressive roles of tumor cell and stromal cell expressing PD-1/PD-L1 in this disease, and presents the development landscape of PD-1/PD-L1 inhibitors, which may provide new curative alternatives for recurrent or metastatic HNSCC. |
format | Online Article Text |
id | pubmed-7531035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75310352020-10-17 The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer Qiao, Xin-wei Jiang, Jian Pang, Xin Huang, Mei-chang Tang, Ya-jie Liang, Xin-hua Tang, Ya-ling Front Immunol Immunology Over the past 10 years, cancer immunotherapy has made significant progress in multiple cancer types and has been gradually been applied to clinical cancer care, in which the programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is one of the most attractive targets. Compared with traditional therapies, the emerging PD-1/PD-L1 blockade immunotherapy exhibited more satisfactory curative effects and lower toxicity for patients with advanced head and neck squamous cell carcinoma (HNSCC). This review analyzes the expression characteristics and clinical significance of PD-1/PD-L1 in HNSCC, the immunosuppressive roles of tumor cell and stromal cell expressing PD-1/PD-L1 in this disease, and presents the development landscape of PD-1/PD-L1 inhibitors, which may provide new curative alternatives for recurrent or metastatic HNSCC. Frontiers Media S.A. 2020-09-18 /pmc/articles/PMC7531035/ /pubmed/33072064 http://dx.doi.org/10.3389/fimmu.2020.01721 Text en Copyright © 2020 Qiao, Jiang, Pang, Huang, Tang, Liang and Tang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Qiao, Xin-wei Jiang, Jian Pang, Xin Huang, Mei-chang Tang, Ya-jie Liang, Xin-hua Tang, Ya-ling The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer |
title | The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer |
title_full | The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer |
title_fullStr | The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer |
title_full_unstemmed | The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer |
title_short | The Evolving Landscape of PD-1/PD-L1 Pathway in Head and Neck Cancer |
title_sort | evolving landscape of pd-1/pd-l1 pathway in head and neck cancer |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531035/ https://www.ncbi.nlm.nih.gov/pubmed/33072064 http://dx.doi.org/10.3389/fimmu.2020.01721 |
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