Cargando…

Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study

BACKGROUND: Different mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory reactions and cachexia which leads to malnutrition (undernutrition). On the other hand, obesity is...

Descripción completa

Detalles Bibliográficos
Autores principales: Guligowska, Agnieszka, Corsonello, Andrea, Pigłowska, Małgorzata, Roller-Wirnsberger, Regina, Wirnsberger, Gerhard, Ärnlöv, Johan, Carlsson, Axel C., Tap, Lisanne, Mattace-Raso, Francesco, Formiga, Francesc, Moreno-Gonzalez, Rafael, Freiberger, Ellen, Sieber, Cornel, Gregorio, Pedro Gil, Martínez, Sara Laínez, Artzi-Medvedik, Rada, Yehoshua, Ilan, Fabbietti, Paolo, Lattanzio, Fabrizia, Kostka, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531088/
https://www.ncbi.nlm.nih.gov/pubmed/33008315
http://dx.doi.org/10.1186/s12877-020-01699-1
_version_ 1783589694574952448
author Guligowska, Agnieszka
Corsonello, Andrea
Pigłowska, Małgorzata
Roller-Wirnsberger, Regina
Wirnsberger, Gerhard
Ärnlöv, Johan
Carlsson, Axel C.
Tap, Lisanne
Mattace-Raso, Francesco
Formiga, Francesc
Moreno-Gonzalez, Rafael
Freiberger, Ellen
Sieber, Cornel
Gregorio, Pedro Gil
Martínez, Sara Laínez
Artzi-Medvedik, Rada
Yehoshua, Ilan
Fabbietti, Paolo
Lattanzio, Fabrizia
Kostka, Tomasz
author_facet Guligowska, Agnieszka
Corsonello, Andrea
Pigłowska, Małgorzata
Roller-Wirnsberger, Regina
Wirnsberger, Gerhard
Ärnlöv, Johan
Carlsson, Axel C.
Tap, Lisanne
Mattace-Raso, Francesco
Formiga, Francesc
Moreno-Gonzalez, Rafael
Freiberger, Ellen
Sieber, Cornel
Gregorio, Pedro Gil
Martínez, Sara Laínez
Artzi-Medvedik, Rada
Yehoshua, Ilan
Fabbietti, Paolo
Lattanzio, Fabrizia
Kostka, Tomasz
author_sort Guligowska, Agnieszka
collection PubMed
description BACKGROUND: Different mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory reactions and cachexia which leads to malnutrition (undernutrition). On the other hand, obesity is an important risk factor for the development and acceleration of CKD. METHODS: In the SCOPE study, community-dwelling persons aged 75 years and over, from 6 European countries and Israel were examined at the baseline phase. We assessed the relationship between anthropometric measures (Body Mass Index (BMI), circumferences of arm (AC), waist (WC), hip (HC), and calf (CC), waist-to-hip ratio - WHR, waist-to-height ratio - WHtR, risk of malnutrition (Mini Nutritional Assessment - MNA), serum albumin) and estimated glomerular filtration rate (eGFR) calculated by Berlin Initiative Study (BIS) equation. RESULTS: We studied 2151 subjects (932 men and 1219 women) with a mean age of 79.5 ± 5.9 years. A total of 1333 (62%) participants had CKD (GRF < 60 ml/min/1.73 m(2)). Negative correlations between eGFR and weight, AC, WC, HC, CC, BMI, WHtR were observed. Positive correlation occurred between eGFR and MNA score (Spearman’s rho = 0.11) and albumin concentration (rho = 0.09). Higher weight, AC, WC, HC, CC, BMI and WHtR increased the odds ratio of CKD; higher MNA (OR = 0.98, 95% CI 0.94–1.0) and higher serum albumin (OR = 0.73, 95% CI 0.53–1.0) were weakly associated with reduced odds. The risk of malnutrition was the highest with eGFR < 30 as compared to eGFR > 60 (OR = 2.95, 95%CI = 1.77–4.94 for MNA < 24; OR = 5.54, 95%CI = 1.66–18.5 for hypoalbuminemia < 3.5 g/dL). CONCLUSION: The population of community dwelling people aged 75+ with CKD shows general features of overweight and obesity with a small prevalence of malnutrition. For anthropometric measures, the strongest association with eGFR and the highest odds of CKD were identified using WC, HC, CC and WHtR. Albumin level and MNA, but not MNA Short Form, indicated an increased odds of malnutrition with a decrease in eGFR.
format Online
Article
Text
id pubmed-7531088
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-75310882020-10-05 Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study Guligowska, Agnieszka Corsonello, Andrea Pigłowska, Małgorzata Roller-Wirnsberger, Regina Wirnsberger, Gerhard Ärnlöv, Johan Carlsson, Axel C. Tap, Lisanne Mattace-Raso, Francesco Formiga, Francesc Moreno-Gonzalez, Rafael Freiberger, Ellen Sieber, Cornel Gregorio, Pedro Gil Martínez, Sara Laínez Artzi-Medvedik, Rada Yehoshua, Ilan Fabbietti, Paolo Lattanzio, Fabrizia Kostka, Tomasz BMC Geriatr Research BACKGROUND: Different mechanisms connect the nutritional status with the occurrence and the course of chronic kidney disease (CKD). The end-stage renal disease is complicated by catabolic inflammatory reactions and cachexia which leads to malnutrition (undernutrition). On the other hand, obesity is an important risk factor for the development and acceleration of CKD. METHODS: In the SCOPE study, community-dwelling persons aged 75 years and over, from 6 European countries and Israel were examined at the baseline phase. We assessed the relationship between anthropometric measures (Body Mass Index (BMI), circumferences of arm (AC), waist (WC), hip (HC), and calf (CC), waist-to-hip ratio - WHR, waist-to-height ratio - WHtR, risk of malnutrition (Mini Nutritional Assessment - MNA), serum albumin) and estimated glomerular filtration rate (eGFR) calculated by Berlin Initiative Study (BIS) equation. RESULTS: We studied 2151 subjects (932 men and 1219 women) with a mean age of 79.5 ± 5.9 years. A total of 1333 (62%) participants had CKD (GRF < 60 ml/min/1.73 m(2)). Negative correlations between eGFR and weight, AC, WC, HC, CC, BMI, WHtR were observed. Positive correlation occurred between eGFR and MNA score (Spearman’s rho = 0.11) and albumin concentration (rho = 0.09). Higher weight, AC, WC, HC, CC, BMI and WHtR increased the odds ratio of CKD; higher MNA (OR = 0.98, 95% CI 0.94–1.0) and higher serum albumin (OR = 0.73, 95% CI 0.53–1.0) were weakly associated with reduced odds. The risk of malnutrition was the highest with eGFR < 30 as compared to eGFR > 60 (OR = 2.95, 95%CI = 1.77–4.94 for MNA < 24; OR = 5.54, 95%CI = 1.66–18.5 for hypoalbuminemia < 3.5 g/dL). CONCLUSION: The population of community dwelling people aged 75+ with CKD shows general features of overweight and obesity with a small prevalence of malnutrition. For anthropometric measures, the strongest association with eGFR and the highest odds of CKD were identified using WC, HC, CC and WHtR. Albumin level and MNA, but not MNA Short Form, indicated an increased odds of malnutrition with a decrease in eGFR. BioMed Central 2020-10-02 /pmc/articles/PMC7531088/ /pubmed/33008315 http://dx.doi.org/10.1186/s12877-020-01699-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Guligowska, Agnieszka
Corsonello, Andrea
Pigłowska, Małgorzata
Roller-Wirnsberger, Regina
Wirnsberger, Gerhard
Ärnlöv, Johan
Carlsson, Axel C.
Tap, Lisanne
Mattace-Raso, Francesco
Formiga, Francesc
Moreno-Gonzalez, Rafael
Freiberger, Ellen
Sieber, Cornel
Gregorio, Pedro Gil
Martínez, Sara Laínez
Artzi-Medvedik, Rada
Yehoshua, Ilan
Fabbietti, Paolo
Lattanzio, Fabrizia
Kostka, Tomasz
Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study
title Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study
title_full Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study
title_fullStr Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study
title_full_unstemmed Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study
title_short Association between kidney function, nutritional status and anthropometric measures in older people: The Screening for CKD among Older People across Europe (SCOPE) study
title_sort association between kidney function, nutritional status and anthropometric measures in older people: the screening for ckd among older people across europe (scope) study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531088/
https://www.ncbi.nlm.nih.gov/pubmed/33008315
http://dx.doi.org/10.1186/s12877-020-01699-1
work_keys_str_mv AT guligowskaagnieszka associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT corsonelloandrea associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT pigłowskamałgorzata associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT rollerwirnsbergerregina associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT wirnsbergergerhard associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT arnlovjohan associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT carlssonaxelc associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT taplisanne associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT mattacerasofrancesco associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT formigafrancesc associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT morenogonzalezrafael associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT freibergerellen associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT siebercornel associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT gregoriopedrogil associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT martinezsaralainez associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT artzimedvedikrada associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT yehoshuailan associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT fabbiettipaolo associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT lattanziofabrizia associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT kostkatomasz associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy
AT associationbetweenkidneyfunctionnutritionalstatusandanthropometricmeasuresinolderpeoplethescreeningforckdamongolderpeopleacrosseuropescopestudy