Mesenchymal stem/stromal cell quality control: validation of mixed lymphocyte reaction assay using flow cytometry according to ICH Q2(R1)

BACKGROUND: Mesenchymal stem/stromal cells (MSC) have immunomodulatory properties, studied in a wide range of diseases. Validated quality controls must confirm this activity in the context of clinical trials. This study presents a method’s validation, assessing MSC’s ability to inhibit lymphocyte pr...

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Detalles Bibliográficos
Autores principales: Nicotra, Tess, Desnos, Aurélie, Halimi, Justine, Antonot, Hélène, Reppel, Loïc, Belmas, Thomas, Freton, Alice, Stranieri, Floriane, Mebarki, Miryam, Larghero, Jérôme, Cras, Audrey, Faivre, Lionel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531151/
https://www.ncbi.nlm.nih.gov/pubmed/33004063
http://dx.doi.org/10.1186/s13287-020-01947-6

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