Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression

Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both in vitro and in vivo. We previously found that CCL2 neutralization in monocyte-derived macr...

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Detalles Bibliográficos
Autores principales: Covino, Daniela Angela, Kaczor-Urbanowicz, Karolina Elżbieta, Lu, Jing, Chiantore, Maria Vincenza, Fiorucci, Gianna, Vescio, Maria Fenicia, Catapano, Laura, Purificato, Cristina, Galluzzo, Clementina Maria, Amici, Roberta, Andreotti, Mauro, Gauzzi, Maria Cristina, Pellegrini, Matteo, Fantuzzi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531389/
https://www.ncbi.nlm.nih.gov/pubmed/33072075
http://dx.doi.org/10.3389/fimmu.2020.02129

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