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Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease

BACKGROUND: Lymphocyte-to-monocyte ratio (LMR) is involved in all stages of coronary atherosclerosis and related to coronary artery disease (CAD). However, the correlation between LMR and the coronary plaque burden of CAD is not clearly elucidated. Therefore, this study aimed to investigate their co...

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Autores principales: Si, Yueqiao, Liu, Jingyi, Shan, Weichao, Zhang, Ying, Han, Chao, Wang, Ruijuan, Sun, Lixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531493/
https://www.ncbi.nlm.nih.gov/pubmed/32097130
http://dx.doi.org/10.1097/MCA.0000000000000857
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author Si, Yueqiao
Liu, Jingyi
Shan, Weichao
Zhang, Ying
Han, Chao
Wang, Ruijuan
Sun, Lixian
author_facet Si, Yueqiao
Liu, Jingyi
Shan, Weichao
Zhang, Ying
Han, Chao
Wang, Ruijuan
Sun, Lixian
author_sort Si, Yueqiao
collection PubMed
description BACKGROUND: Lymphocyte-to-monocyte ratio (LMR) is involved in all stages of coronary atherosclerosis and related to coronary artery disease (CAD). However, the correlation between LMR and the coronary plaque burden of CAD is not clearly elucidated. Therefore, this study aimed to investigate their correlation in patients with CAD. METHODS: A total of 1953 consecutive eligible inpatients with suspected CAD were retrospectively included in this study. They were assigned into CAD (n = 564) and non-CAD groups (n = 1389). All patients underwent coronary computed tomographic angiography to evaluate coronary stenosis and coronary artery calcification (CAC). Spearman’s tests were used to analyze the correlation between CAC score and LMR. Multivariate logistic regression models were set up to assess the risk factors of CAD. RESULTS: Patients with CAD had lower LMR value than patients without CAD (P = 0.001). LMR was negatively correlated with CAC score and was an independent risk factor of CAC score (P < 0.05). Multivariate logistic regression model showed that LMR ≤4.8 was a newly independent risk factor of CAD (all P < 0.05). Additionally, the new risk score model was compared with the Framingham model and showed that NRI was 4.9%, which proved that the new risk score model improved the prediction capability of CAD. CONCLUSION: LMR ≤4.8 is a new independent risk factor of CAD. LMR value was negatively correlated with CAC score and could be used as a new marker to evaluate the coronary plaque burden of CAD.
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spelling pubmed-75314932020-10-14 Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease Si, Yueqiao Liu, Jingyi Shan, Weichao Zhang, Ying Han, Chao Wang, Ruijuan Sun, Lixian Coron Artery Dis Lipids and Inflammation BACKGROUND: Lymphocyte-to-monocyte ratio (LMR) is involved in all stages of coronary atherosclerosis and related to coronary artery disease (CAD). However, the correlation between LMR and the coronary plaque burden of CAD is not clearly elucidated. Therefore, this study aimed to investigate their correlation in patients with CAD. METHODS: A total of 1953 consecutive eligible inpatients with suspected CAD were retrospectively included in this study. They were assigned into CAD (n = 564) and non-CAD groups (n = 1389). All patients underwent coronary computed tomographic angiography to evaluate coronary stenosis and coronary artery calcification (CAC). Spearman’s tests were used to analyze the correlation between CAC score and LMR. Multivariate logistic regression models were set up to assess the risk factors of CAD. RESULTS: Patients with CAD had lower LMR value than patients without CAD (P = 0.001). LMR was negatively correlated with CAC score and was an independent risk factor of CAC score (P < 0.05). Multivariate logistic regression model showed that LMR ≤4.8 was a newly independent risk factor of CAD (all P < 0.05). Additionally, the new risk score model was compared with the Framingham model and showed that NRI was 4.9%, which proved that the new risk score model improved the prediction capability of CAD. CONCLUSION: LMR ≤4.8 is a new independent risk factor of CAD. LMR value was negatively correlated with CAC score and could be used as a new marker to evaluate the coronary plaque burden of CAD. Lippincott Williams & Wilkins 2020-02-22 2020-11 /pmc/articles/PMC7531493/ /pubmed/32097130 http://dx.doi.org/10.1097/MCA.0000000000000857 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CC-BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Lipids and Inflammation
Si, Yueqiao
Liu, Jingyi
Shan, Weichao
Zhang, Ying
Han, Chao
Wang, Ruijuan
Sun, Lixian
Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease
title Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease
title_full Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease
title_fullStr Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease
title_full_unstemmed Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease
title_short Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease
title_sort association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease
topic Lipids and Inflammation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531493/
https://www.ncbi.nlm.nih.gov/pubmed/32097130
http://dx.doi.org/10.1097/MCA.0000000000000857
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