(18)F-FBPA PET in Sarcoidosis: Comparison to Inflammation-Related Uptake on FDG PET

A 68-year-old man with sarcoidosis showed high (18)F-FDG uptake in the mediastinal and hilar lymph nodes on (18)F-FDG PET, suggesting active inflammation. (18)F-fluoro-boronophenylalanine (FBPA) PET showed no significant uptake in the mediastinal and hilar lymph nodes, suggesting its cancer specific...

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Detalles Bibliográficos
Autores principales: Watabe, Tadashi, Shimamoto, Hiroaki, Naka, Sadahiro, Kamiya, Takashi, Murakami, Shumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531499/
https://www.ncbi.nlm.nih.gov/pubmed/32969900
http://dx.doi.org/10.1097/RLU.0000000000003274
Descripción
Sumario:A 68-year-old man with sarcoidosis showed high (18)F-FDG uptake in the mediastinal and hilar lymph nodes on (18)F-FDG PET, suggesting active inflammation. (18)F-fluoro-boronophenylalanine (FBPA) PET showed no significant uptake in the mediastinal and hilar lymph nodes, suggesting its cancer specificity as a substrate of l-type amino acid transporter 1. (18)F-fluoro-boronophenylalanine PET can be used for precise evaluation in oncology when the differentiation between inflammation and metastasis is inconclusive on (18)F-FDG PET.

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