Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity

The long circulating half-life and inherently bivalent architecture of IgGs provide an ideal vehicle for presenting otherwise short-lived G-protein-coupled receptor agonists in a format that enables avidity-driven enhancement of potency. Here, we describe the site-specific conjugation of a dual agon...

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Detalles Bibliográficos
Autores principales: Camacho, Raul C., You, Seohee, D’Aquino, Katharine E., Li, Wenyu, Wang, Yuanping, Gunnet, Joseph, Littrell, James, Qi, Jian Shen, Kang, Lijuan, Jian, Wenying, MacDonald, Mary, Tat, Timothy, Steiner, Derek, Zhang, Yue-Mei, Lanter, James, Patch, Raymond, Zhang, Rui, Li, Jiali, Edavettal, Suzanne, Edwards, Wilson, Dinh, Thai, Wang, Li Ying, Connor, Judy, Hunter, Michael, Chi, Ellen, Swanson, Ronald V., Leonard, James N., Case, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531507/
https://www.ncbi.nlm.nih.gov/pubmed/32744157
http://dx.doi.org/10.1080/19420862.2020.1794687

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