COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors

Conditionally active COBRA™ (COnditional Bispecific Redirected Activation) T cell engagers are engineered to overcome the limitations of inherently active first-generation T cell engagers, which are unable to discern between tumor and healthy tissues. Designed to be administered as prodrugs, COBRAs...

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Detalles Bibliográficos
Autores principales: Panchal, Anand, Seto, Pui, Wall, Russell, Hillier, Brian J., Zhu, Ying, Krakow, Jessica, Datt, Aakash, Pongo, Elizabeth, Bagheri, Andisheh, Chen, Tseng-Hui T., Degenhardt, Jeremiah D., Culp, Patricia A., Dettling, Danielle E., Vinogradova, Maia V., May, Chad, DuBridge, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531513/
https://www.ncbi.nlm.nih.gov/pubmed/32684124
http://dx.doi.org/10.1080/19420862.2020.1792130

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