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Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry
Therapeutic monoclonal antibodies (mAbs) are highly complex proteins that must be exhaustively characterized according to the regulatory authorities' recommendations. MAbs display micro-heterogeneity mainly due to their post-translational modifications, but also to their susceptibility to chemi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531515/ https://www.ncbi.nlm.nih.gov/pubmed/32633190 http://dx.doi.org/10.1080/19420862.2020.1781743 |