A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model

Biotherapeutic drugs against tumor necrosis factor (TNF) are effective treatments for moderate to severe inflammatory bowel disease (IBD). Here, we evaluated CNTO 5048, an antimurine TNF surrogate monoclonal antibody (mAb), in a CD45RB(high) adoptive T cell transfer mouse colitis model, which allows...

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Detalles Bibliográficos
Autores principales: Zheng, Songmao, Niu, Jin, Geist, Brian, Fink, Damien, Xu, Zhenhua, Zhou, Honghui, Wang, Weirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531524/
https://www.ncbi.nlm.nih.gov/pubmed/32967523
http://dx.doi.org/10.1080/19420862.2020.1813962

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