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Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently, a VHH is engrafted onto constant region CH1...

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Detalles Bibliográficos
Autores principales:	Pekar, Lukas, Busch, Michael, Valldorf, Bernhard, Hinz, Steffen C., Toleikis, Lars, Krah, Simon, Zielonka, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531565/ https://www.ncbi.nlm.nih.gov/pubmed/32887531 http://dx.doi.org/10.1080/19420862.2020.1812210

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