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Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates

The terminal sugars of Fc glycans can influence the Fc-dependent biological activities of monoclonal antibody therapeutics. Afucosylated N-glycans have been shown to significantly alter binding to FcγRIIIa and affect antibody-dependent cell-mediated cytotoxicity (ADCC). Therefore, in order to mainta...

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Detalles Bibliográficos
Autores principales:	Kwiatkowski, Allyson, Co, Carl, Kameoka, Sei, Zhang, An, Coughlin, John, Cameron, Tom, Chiao, Eric, Bergelson, Svetlana, Schmid Mason, Cullen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531570/ https://www.ncbi.nlm.nih.gov/pubmed/32812835 http://dx.doi.org/10.1080/19420862.2020.1803645

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