Engineered Fc-glycosylation switch to eliminate antibody effector function

Antibodies mediate effector functions through Fcγ receptor (FcγR) interactions and complement activation, causing cytokine release, degranulation, phagocytosis, and cell death. They are often undesired for development of therapeutic antibodies where only antigen binding or neutralization would be id...

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Detalles Bibliográficos
Autores principales: Zhou, Qun, Jaworski, Julie, Zhou, Yanfeng, Valente, Delphine, Cotton, Joanne, Honey, Denise, Boudanova, Ekaterina, Beninga, Jochen, Rao, Ercole, Wei, Ronnie, Mauriac, Christine, Pan, Clark, Park, Anna, Qiu, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531572/
https://www.ncbi.nlm.nih.gov/pubmed/32892677
http://dx.doi.org/10.1080/19420862.2020.1814583

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