Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity

Preferential interactions of excipients with the antibody surface govern their effect on the stability of antibodies in solution. We probed the preferential interactions of proline, arginine.HCl (Arg.HCl), and NaCl with three therapeutically relevant IgG1 antibodies via experiment and simulation. Wi...

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Detalles Bibliográficos
Autores principales: Cloutier, Theresa K., Sudrik, Chaitanya, Mody, Neil, Hasige, Sathish A., Trout, Bernhardt L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531574/
https://www.ncbi.nlm.nih.gov/pubmed/32938318
http://dx.doi.org/10.1080/19420862.2020.1816312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531574/
https://www.ncbi.nlm.nih.gov/pubmed/32938318
http://dx.doi.org/10.1080/19420862.2020.1816312

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