Cytokine Storms in Cancer and COVID-19

During the COVID-19 pandemic, research on “cytokine storms” has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-...

Descripción completa

Detalles Bibliográficos
Autores principales: Turnquist, Casmir, Ryan, Bríd M., Horikawa, Izumi, Harris, Brent T., Harris, Curtis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531591/
https://www.ncbi.nlm.nih.gov/pubmed/33038939
http://dx.doi.org/10.1016/j.ccell.2020.09.019
Descripción
Sumario:During the COVID-19 pandemic, research on “cytokine storms” has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. Interleukin-6 (IL-6) has emerged as a key component of the immune response to SARS-CoV-2, such that the repurposing of anti-IL-6 therapeutics for COVID-19 is now a major line of investigation, with several ongoing clinical trials. We lay a framework for understanding the role of IL-6 in the context of cancer research and COVID-19 and suggest how lessons learned from cancer research may impact SARS-CoV-2 research and vice versa.

Ejemplares similares