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Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series
BACKGROUND: Coronavirus disease 2019 is a pandemic with no specific therapeutic agents or vaccination. Small published case series on critically ill adults suggest improvements in clinical status with minimal adverse events when patients receive coronavirus disease 2019 convalescent plasma, but data...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531759/ https://www.ncbi.nlm.nih.gov/pubmed/33063037 http://dx.doi.org/10.1097/CCE.0000000000000237 |
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author | Schwartz, Stephanie P. Thompson, Peyton Smith, Melissa Lercher, Daniel M. Rimland, Casey A. Bartelt, Luther Park, Yara A. Weiss, Susan Markmann, Alena Janda Raut, Rajendra Premkumar, Lakshmanane Kuruc, JoAnn Willis, Zachary |
author_facet | Schwartz, Stephanie P. Thompson, Peyton Smith, Melissa Lercher, Daniel M. Rimland, Casey A. Bartelt, Luther Park, Yara A. Weiss, Susan Markmann, Alena Janda Raut, Rajendra Premkumar, Lakshmanane Kuruc, JoAnn Willis, Zachary |
author_sort | Schwartz, Stephanie P. |
collection | PubMed |
description | BACKGROUND: Coronavirus disease 2019 is a pandemic with no specific therapeutic agents or vaccination. Small published case series on critically ill adults suggest improvements in clinical status with minimal adverse events when patients receive coronavirus disease 2019 convalescent plasma, but data on critically ill pediatric patients are lacking. We report a series of four critically ill pediatric patients with acute respiratory failure who received coronavirus disease 2019 convalescent plasma as a treatment strategy for severe disease. CASE SUMMARY: Patients ranged in age from 5 to 16 years old. All patients received coronavirus disease 2019 convalescent plasma within the first 26 hours of hospitalization. Additional disease modifying agents were also used. All patients made a full recovery and were discharged home off of oxygen support. No adverse events occurred from the coronavirus disease 2019 convalescent plasma transfusions. CONCLUSION: Coronavirus disease 2019 convalescent plasma is a feasible therapy for critically ill pediatric patients infected with severe acute respiratory syndrome coronavirus 2. Well-designed clinical trials are necessary to determine overall safety and efficacy of coronavirus disease 2019 convalescent plasma and additional treatment modalities in pediatric patients. |
format | Online Article Text |
id | pubmed-7531759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-75317592020-10-14 Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series Schwartz, Stephanie P. Thompson, Peyton Smith, Melissa Lercher, Daniel M. Rimland, Casey A. Bartelt, Luther Park, Yara A. Weiss, Susan Markmann, Alena Janda Raut, Rajendra Premkumar, Lakshmanane Kuruc, JoAnn Willis, Zachary Crit Care Explor Case Report BACKGROUND: Coronavirus disease 2019 is a pandemic with no specific therapeutic agents or vaccination. Small published case series on critically ill adults suggest improvements in clinical status with minimal adverse events when patients receive coronavirus disease 2019 convalescent plasma, but data on critically ill pediatric patients are lacking. We report a series of four critically ill pediatric patients with acute respiratory failure who received coronavirus disease 2019 convalescent plasma as a treatment strategy for severe disease. CASE SUMMARY: Patients ranged in age from 5 to 16 years old. All patients received coronavirus disease 2019 convalescent plasma within the first 26 hours of hospitalization. Additional disease modifying agents were also used. All patients made a full recovery and were discharged home off of oxygen support. No adverse events occurred from the coronavirus disease 2019 convalescent plasma transfusions. CONCLUSION: Coronavirus disease 2019 convalescent plasma is a feasible therapy for critically ill pediatric patients infected with severe acute respiratory syndrome coronavirus 2. Well-designed clinical trials are necessary to determine overall safety and efficacy of coronavirus disease 2019 convalescent plasma and additional treatment modalities in pediatric patients. Lippincott Williams & Wilkins 2020-10-01 /pmc/articles/PMC7531759/ /pubmed/33063037 http://dx.doi.org/10.1097/CCE.0000000000000237 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Case Report Schwartz, Stephanie P. Thompson, Peyton Smith, Melissa Lercher, Daniel M. Rimland, Casey A. Bartelt, Luther Park, Yara A. Weiss, Susan Markmann, Alena Janda Raut, Rajendra Premkumar, Lakshmanane Kuruc, JoAnn Willis, Zachary Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series |
title | Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series |
title_full | Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series |
title_fullStr | Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series |
title_full_unstemmed | Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series |
title_short | Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series |
title_sort | convalescent plasma therapy in four critically ill pediatric patients with coronavirus disease 2019: a case series |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7531759/ https://www.ncbi.nlm.nih.gov/pubmed/33063037 http://dx.doi.org/10.1097/CCE.0000000000000237 |
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