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Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

Although the primate visual system has been extensively studied, detailed spatial organization of white matter fiber tracts carrying visual information between areas has not been fully established. This is mainly due to the large gap between tracer studies and diffusion-weighted MRI studies, which f...

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Autores principales: Takemura, Hiromasa, Palomero-Gallagher, Nicola, Axer, Markus, Gräßel, David, Jorgensen, Matthew J, Woods, Roger, Zilles, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532002/
https://www.ncbi.nlm.nih.gov/pubmed/32844747
http://dx.doi.org/10.7554/eLife.55444
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author Takemura, Hiromasa
Palomero-Gallagher, Nicola
Axer, Markus
Gräßel, David
Jorgensen, Matthew J
Woods, Roger
Zilles, Karl
author_facet Takemura, Hiromasa
Palomero-Gallagher, Nicola
Axer, Markus
Gräßel, David
Jorgensen, Matthew J
Woods, Roger
Zilles, Karl
author_sort Takemura, Hiromasa
collection PubMed
description Although the primate visual system has been extensively studied, detailed spatial organization of white matter fiber tracts carrying visual information between areas has not been fully established. This is mainly due to the large gap between tracer studies and diffusion-weighted MRI studies, which focus on specific axonal connections and macroscale organization of fiber tracts, respectively. Here we used 3D polarization light imaging (3D-PLI), which enables direct visualization of fiber tracts at micrometer resolution, to identify and visualize fiber tracts of the visual system, such as stratum sagittale, inferior longitudinal fascicle, vertical occipital fascicle, tapetum and dorsal occipital bundle in vervet monkey brains. Moreover, 3D-PLI data provide detailed information on cortical projections of these tracts, distinction between neighboring tracts, and novel short-range pathways. This work provides essential information for interpretation of functional and diffusion-weighted MRI data, as well as revision of wiring diagrams based upon observations in the vervet visual system.
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spelling pubmed-75320022020-10-05 Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system Takemura, Hiromasa Palomero-Gallagher, Nicola Axer, Markus Gräßel, David Jorgensen, Matthew J Woods, Roger Zilles, Karl eLife Neuroscience Although the primate visual system has been extensively studied, detailed spatial organization of white matter fiber tracts carrying visual information between areas has not been fully established. This is mainly due to the large gap between tracer studies and diffusion-weighted MRI studies, which focus on specific axonal connections and macroscale organization of fiber tracts, respectively. Here we used 3D polarization light imaging (3D-PLI), which enables direct visualization of fiber tracts at micrometer resolution, to identify and visualize fiber tracts of the visual system, such as stratum sagittale, inferior longitudinal fascicle, vertical occipital fascicle, tapetum and dorsal occipital bundle in vervet monkey brains. Moreover, 3D-PLI data provide detailed information on cortical projections of these tracts, distinction between neighboring tracts, and novel short-range pathways. This work provides essential information for interpretation of functional and diffusion-weighted MRI data, as well as revision of wiring diagrams based upon observations in the vervet visual system. eLife Sciences Publications, Ltd 2020-08-26 /pmc/articles/PMC7532002/ /pubmed/32844747 http://dx.doi.org/10.7554/eLife.55444 Text en © 2020, Takemura et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Takemura, Hiromasa
Palomero-Gallagher, Nicola
Axer, Markus
Gräßel, David
Jorgensen, Matthew J
Woods, Roger
Zilles, Karl
Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
title Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
title_full Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
title_fullStr Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
title_full_unstemmed Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
title_short Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
title_sort anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532002/
https://www.ncbi.nlm.nih.gov/pubmed/32844747
http://dx.doi.org/10.7554/eLife.55444
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