Cargando…
Role of miRNA-424 in Cancers
microRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a posttranscriptional level. miRNA has gained increasing interest in recent years, both in research and clinical fields. miRNAs have been found to play an important role in various diseases, particularly cancer...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532073/ https://www.ncbi.nlm.nih.gov/pubmed/33061443 http://dx.doi.org/10.2147/OTT.S266541 |
_version_ | 1783589848159879168 |
---|---|
author | Li, Shulin Wu, Yuqi Zhang, Jiawei Sun, Hao Wang, Xiangwei |
author_facet | Li, Shulin Wu, Yuqi Zhang, Jiawei Sun, Hao Wang, Xiangwei |
author_sort | Li, Shulin |
collection | PubMed |
description | microRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a posttranscriptional level. miRNA has gained increasing interest in recent years, both in research and clinical fields. miRNAs have been found to play an important role in various diseases, particularly cancer. Aberrant miR-424 expression is found in several tumors where they can function as either oncogenes or tumor-suppressor genes. Meanwhile, miR-424 is also affected by the reorganization of many other non-coding RNAs such as lncRNA and cirRNA. Several studies have found that miR-424 participates in proliferation, differentiation, apoptosis, invasion, angiogenesis, and drug resistance, and plays an important role in the tumorigenesis and progression of tumors. This review will focus on the recent progress of research on miR-424 in tumors. |
format | Online Article Text |
id | pubmed-7532073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75320732020-10-14 Role of miRNA-424 in Cancers Li, Shulin Wu, Yuqi Zhang, Jiawei Sun, Hao Wang, Xiangwei Onco Targets Ther Review microRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a posttranscriptional level. miRNA has gained increasing interest in recent years, both in research and clinical fields. miRNAs have been found to play an important role in various diseases, particularly cancer. Aberrant miR-424 expression is found in several tumors where they can function as either oncogenes or tumor-suppressor genes. Meanwhile, miR-424 is also affected by the reorganization of many other non-coding RNAs such as lncRNA and cirRNA. Several studies have found that miR-424 participates in proliferation, differentiation, apoptosis, invasion, angiogenesis, and drug resistance, and plays an important role in the tumorigenesis and progression of tumors. This review will focus on the recent progress of research on miR-424 in tumors. Dove 2020-09-28 /pmc/articles/PMC7532073/ /pubmed/33061443 http://dx.doi.org/10.2147/OTT.S266541 Text en © 2020 Li et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Li, Shulin Wu, Yuqi Zhang, Jiawei Sun, Hao Wang, Xiangwei Role of miRNA-424 in Cancers |
title | Role of miRNA-424 in Cancers |
title_full | Role of miRNA-424 in Cancers |
title_fullStr | Role of miRNA-424 in Cancers |
title_full_unstemmed | Role of miRNA-424 in Cancers |
title_short | Role of miRNA-424 in Cancers |
title_sort | role of mirna-424 in cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532073/ https://www.ncbi.nlm.nih.gov/pubmed/33061443 http://dx.doi.org/10.2147/OTT.S266541 |
work_keys_str_mv | AT lishulin roleofmirna424incancers AT wuyuqi roleofmirna424incancers AT zhangjiawei roleofmirna424incancers AT sunhao roleofmirna424incancers AT wangxiangwei roleofmirna424incancers |