Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule

Trigonelline (TGN; 1-methylpyridin-1-ium-3-carboxylate) is a widely distributed alkaloid derived from plants. Since we previously found a neurite outgrowth effect of TGN, we hypothesised that TGN might help to improve memory deficits. Here, the efficacy of TGN in restoring amyloid β (Aβ)-induced axo...

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Detalles Bibliográficos
Autores principales: Farid, Mai M., Yang, Ximeng, Kuboyama, Tomoharu, Tohda, Chihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532147/
https://www.ncbi.nlm.nih.gov/pubmed/33009465
http://dx.doi.org/10.1038/s41598-020-73514-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532147/
https://www.ncbi.nlm.nih.gov/pubmed/33009465
http://dx.doi.org/10.1038/s41598-020-73514-1

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