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Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice

Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS. However, the effect of acute SDS on sleep/wa...

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Autores principales: Feng, Xiang, Zhao, Hui-Ying, Shao, Yu-Jin, Lou, Hui-Fang, Zhu, Li-Ya, Duan, Shumin, Yu, Yan-Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532235/
https://www.ncbi.nlm.nih.gov/pubmed/32096115
http://dx.doi.org/10.1007/s12264-020-00473-y
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author Feng, Xiang
Zhao, Hui-Ying
Shao, Yu-Jin
Lou, Hui-Fang
Zhu, Li-Ya
Duan, Shumin
Yu, Yan-Qin
author_facet Feng, Xiang
Zhao, Hui-Ying
Shao, Yu-Jin
Lou, Hui-Fang
Zhu, Li-Ya
Duan, Shumin
Yu, Yan-Qin
author_sort Feng, Xiang
collection PubMed
description Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS. However, the effect of acute SDS on sleep/wake behavior in mice varies between studies. In addition, whether sleep changes in response to stress contribute to anxiety is not well established. Here, we first investigated the effects of acute SDS on sleep/wake states in the active period in mice. Our results showed that total sleep time (time in rapid eye-movement [REM] and non-REM [NREM] sleep) increased in the active period after acute SDS. NREM sleep increased mainly during the first 3 h after SDS, while REM sleep increased at a later time. Then, we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute SDS. Mice deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state, while in mice with ad libitum sleep the anxiety rapidly faded away. Altogether, our findings suggest an anxiolytic effect of NREM sleep, and indicate a potential therapeutic strategy for anxiety.
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spelling pubmed-75322352020-10-19 Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice Feng, Xiang Zhao, Hui-Ying Shao, Yu-Jin Lou, Hui-Fang Zhu, Li-Ya Duan, Shumin Yu, Yan-Qin Neurosci Bull Original Article Social defeat stress (SDS) plays a major role in the pathogenesis of psychiatric disorders like anxiety and depression. Sleep is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute SDS. However, the effect of acute SDS on sleep/wake behavior in mice varies between studies. In addition, whether sleep changes in response to stress contribute to anxiety is not well established. Here, we first investigated the effects of acute SDS on sleep/wake states in the active period in mice. Our results showed that total sleep time (time in rapid eye-movement [REM] and non-REM [NREM] sleep) increased in the active period after acute SDS. NREM sleep increased mainly during the first 3 h after SDS, while REM sleep increased at a later time. Then, we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute SDS. Mice deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state, while in mice with ad libitum sleep the anxiety rapidly faded away. Altogether, our findings suggest an anxiolytic effect of NREM sleep, and indicate a potential therapeutic strategy for anxiety. Springer Singapore 2020-02-24 /pmc/articles/PMC7532235/ /pubmed/32096115 http://dx.doi.org/10.1007/s12264-020-00473-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Feng, Xiang
Zhao, Hui-Ying
Shao, Yu-Jin
Lou, Hui-Fang
Zhu, Li-Ya
Duan, Shumin
Yu, Yan-Qin
Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
title Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
title_full Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
title_fullStr Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
title_full_unstemmed Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
title_short Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice
title_sort anxiolytic effect of increased nrem sleep after acute social defeat stress in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532235/
https://www.ncbi.nlm.nih.gov/pubmed/32096115
http://dx.doi.org/10.1007/s12264-020-00473-y
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