Cargando…
Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
BACKGROUND: The majority of beta thalassemia major (β‐TM) patients suffer from cardiac disease, while a significant proportion of them die suddenly. Twelve‐lead and signal‐averaged electrocardiography (SAECG) are simple, inexpensive, readily available tools for identifying an unfavorable arrhythmiol...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532271/ https://www.ncbi.nlm.nih.gov/pubmed/33024470 http://dx.doi.org/10.1002/joa3.12412 |
_version_ | 1783589890490892288 |
---|---|
author | Patsourakos, Dimitrios Gatzoulis, Konstantinos A. Aggeli, Constantina Delicou, Sophia Dimitroglou, Yannis Xydaki, Katerina Toutouzas, Konstantinos Androulakis, Aristeidis Tousoulis, Dimitrios |
author_facet | Patsourakos, Dimitrios Gatzoulis, Konstantinos A. Aggeli, Constantina Delicou, Sophia Dimitroglou, Yannis Xydaki, Katerina Toutouzas, Konstantinos Androulakis, Aristeidis Tousoulis, Dimitrios |
author_sort | Patsourakos, Dimitrios |
collection | PubMed |
description | BACKGROUND: The majority of beta thalassemia major (β‐TM) patients suffer from cardiac disease, while a significant proportion of them die suddenly. Twelve‐lead and signal‐averaged electrocardiography (SAECG) are simple, inexpensive, readily available tools for identifying an unfavorable arrhythmiological substrate by detecting the presence of arrhythmias, conduction abnormalities, and late potentials (LPs) in these patients. METHODS: A total of 47 β‐TM patients and 30 healthy controls were submitted to 12‐lead and signal‐averaged electrocardiography. Basic electrocardiographic parameters and prevalence of LPs were recorded. Basic echocardiographic parameters were estimated by transthoracic echocardiography. T2* was calculated by cardiac magnetic resonance imaging wherever available. RESULTS: β‐TM patients demonstrated a more prolonged PR interval (167.74 msec vs 147.07 msec) (P = .043), a higher prevalence of PR prolongation (21.05% vs 0%) (P = .013), and a higher prevalence of LPs (18/47, 38.3% vs 2/30, 6.7%) (P = .002) compared with controls. The prevalence of atrial fibrillation among b‐TM patients was estimated at 10.64%. Patients had also greater E/e′ ratio (8.35, SD = 2.2 vs 7, SD = 2.07) (P = .012) and LAVI (30.7 mL/m(2), SD = 8.76 vs 24.6 mL/m(2), SD = 6.57) (P = .002) than controls. Regression analysis showed that QTc and LAVI could correctly predict the presence of LPs in the 80.9% of the patients. CONCLUSIONS: β‐TM patients have a higher prevalence of a prolonged PR interval, atrial fibrillation, and LPs. Twelve‐lead and SAECG performance was feasible in all subjects and constitutes a readily available tool for assessing myocardial electrophysiological alterations in this patient group. |
format | Online Article Text |
id | pubmed-7532271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75322712020-10-05 Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients Patsourakos, Dimitrios Gatzoulis, Konstantinos A. Aggeli, Constantina Delicou, Sophia Dimitroglou, Yannis Xydaki, Katerina Toutouzas, Konstantinos Androulakis, Aristeidis Tousoulis, Dimitrios J Arrhythm Original Articles BACKGROUND: The majority of beta thalassemia major (β‐TM) patients suffer from cardiac disease, while a significant proportion of them die suddenly. Twelve‐lead and signal‐averaged electrocardiography (SAECG) are simple, inexpensive, readily available tools for identifying an unfavorable arrhythmiological substrate by detecting the presence of arrhythmias, conduction abnormalities, and late potentials (LPs) in these patients. METHODS: A total of 47 β‐TM patients and 30 healthy controls were submitted to 12‐lead and signal‐averaged electrocardiography. Basic electrocardiographic parameters and prevalence of LPs were recorded. Basic echocardiographic parameters were estimated by transthoracic echocardiography. T2* was calculated by cardiac magnetic resonance imaging wherever available. RESULTS: β‐TM patients demonstrated a more prolonged PR interval (167.74 msec vs 147.07 msec) (P = .043), a higher prevalence of PR prolongation (21.05% vs 0%) (P = .013), and a higher prevalence of LPs (18/47, 38.3% vs 2/30, 6.7%) (P = .002) compared with controls. The prevalence of atrial fibrillation among b‐TM patients was estimated at 10.64%. Patients had also greater E/e′ ratio (8.35, SD = 2.2 vs 7, SD = 2.07) (P = .012) and LAVI (30.7 mL/m(2), SD = 8.76 vs 24.6 mL/m(2), SD = 6.57) (P = .002) than controls. Regression analysis showed that QTc and LAVI could correctly predict the presence of LPs in the 80.9% of the patients. CONCLUSIONS: β‐TM patients have a higher prevalence of a prolonged PR interval, atrial fibrillation, and LPs. Twelve‐lead and SAECG performance was feasible in all subjects and constitutes a readily available tool for assessing myocardial electrophysiological alterations in this patient group. John Wiley and Sons Inc. 2020-07-26 /pmc/articles/PMC7532271/ /pubmed/33024470 http://dx.doi.org/10.1002/joa3.12412 Text en © 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Patsourakos, Dimitrios Gatzoulis, Konstantinos A. Aggeli, Constantina Delicou, Sophia Dimitroglou, Yannis Xydaki, Katerina Toutouzas, Konstantinos Androulakis, Aristeidis Tousoulis, Dimitrios Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients |
title | Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients |
title_full | Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients |
title_fullStr | Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients |
title_full_unstemmed | Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients |
title_short | Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients |
title_sort | twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532271/ https://www.ncbi.nlm.nih.gov/pubmed/33024470 http://dx.doi.org/10.1002/joa3.12412 |
work_keys_str_mv | AT patsourakosdimitrios twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT gatzouliskonstantinosa twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT aggeliconstantina twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT delicousophia twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT dimitroglouyannis twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT xydakikaterina twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT toutouzaskonstantinos twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT androulakisaristeidis twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients AT tousoulisdimitrios twelveleadandsignalaveragedelectrocardiographicparametersamongbetathalassemiamajorpatients |