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Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients

BACKGROUND: The majority of beta thalassemia major (β‐TM) patients suffer from cardiac disease, while a significant proportion of them die suddenly. Twelve‐lead and signal‐averaged electrocardiography (SAECG) are simple, inexpensive, readily available tools for identifying an unfavorable arrhythmiol...

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Autores principales: Patsourakos, Dimitrios, Gatzoulis, Konstantinos A., Aggeli, Constantina, Delicou, Sophia, Dimitroglou, Yannis, Xydaki, Katerina, Toutouzas, Konstantinos, Androulakis, Aristeidis, Tousoulis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532271/
https://www.ncbi.nlm.nih.gov/pubmed/33024470
http://dx.doi.org/10.1002/joa3.12412
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author Patsourakos, Dimitrios
Gatzoulis, Konstantinos A.
Aggeli, Constantina
Delicou, Sophia
Dimitroglou, Yannis
Xydaki, Katerina
Toutouzas, Konstantinos
Androulakis, Aristeidis
Tousoulis, Dimitrios
author_facet Patsourakos, Dimitrios
Gatzoulis, Konstantinos A.
Aggeli, Constantina
Delicou, Sophia
Dimitroglou, Yannis
Xydaki, Katerina
Toutouzas, Konstantinos
Androulakis, Aristeidis
Tousoulis, Dimitrios
author_sort Patsourakos, Dimitrios
collection PubMed
description BACKGROUND: The majority of beta thalassemia major (β‐TM) patients suffer from cardiac disease, while a significant proportion of them die suddenly. Twelve‐lead and signal‐averaged electrocardiography (SAECG) are simple, inexpensive, readily available tools for identifying an unfavorable arrhythmiological substrate by detecting the presence of arrhythmias, conduction abnormalities, and late potentials (LPs) in these patients. METHODS: A total of 47 β‐TM patients and 30 healthy controls were submitted to 12‐lead and signal‐averaged electrocardiography. Basic electrocardiographic parameters and prevalence of LPs were recorded. Basic echocardiographic parameters were estimated by transthoracic echocardiography. T2* was calculated by cardiac magnetic resonance imaging wherever available. RESULTS: β‐TM patients demonstrated a more prolonged PR interval (167.74 msec vs 147.07 msec) (P = .043), a higher prevalence of PR prolongation (21.05% vs 0%) (P = .013), and a higher prevalence of LPs (18/47, 38.3% vs 2/30, 6.7%) (P = .002) compared with controls. The prevalence of atrial fibrillation among b‐TM patients was estimated at 10.64%. Patients had also greater E/e′ ratio (8.35, SD = 2.2 vs 7, SD = 2.07) (P = .012) and LAVI (30.7 mL/m(2), SD = 8.76 vs 24.6 mL/m(2), SD = 6.57) (P = .002) than controls. Regression analysis showed that QTc and LAVI could correctly predict the presence of LPs in the 80.9% of the patients. CONCLUSIONS: β‐TM patients have a higher prevalence of a prolonged PR interval, atrial fibrillation, and LPs. Twelve‐lead and SAECG performance was feasible in all subjects and constitutes a readily available tool for assessing myocardial electrophysiological alterations in this patient group.
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spelling pubmed-75322712020-10-05 Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients Patsourakos, Dimitrios Gatzoulis, Konstantinos A. Aggeli, Constantina Delicou, Sophia Dimitroglou, Yannis Xydaki, Katerina Toutouzas, Konstantinos Androulakis, Aristeidis Tousoulis, Dimitrios J Arrhythm Original Articles BACKGROUND: The majority of beta thalassemia major (β‐TM) patients suffer from cardiac disease, while a significant proportion of them die suddenly. Twelve‐lead and signal‐averaged electrocardiography (SAECG) are simple, inexpensive, readily available tools for identifying an unfavorable arrhythmiological substrate by detecting the presence of arrhythmias, conduction abnormalities, and late potentials (LPs) in these patients. METHODS: A total of 47 β‐TM patients and 30 healthy controls were submitted to 12‐lead and signal‐averaged electrocardiography. Basic electrocardiographic parameters and prevalence of LPs were recorded. Basic echocardiographic parameters were estimated by transthoracic echocardiography. T2* was calculated by cardiac magnetic resonance imaging wherever available. RESULTS: β‐TM patients demonstrated a more prolonged PR interval (167.74 msec vs 147.07 msec) (P = .043), a higher prevalence of PR prolongation (21.05% vs 0%) (P = .013), and a higher prevalence of LPs (18/47, 38.3% vs 2/30, 6.7%) (P = .002) compared with controls. The prevalence of atrial fibrillation among b‐TM patients was estimated at 10.64%. Patients had also greater E/e′ ratio (8.35, SD = 2.2 vs 7, SD = 2.07) (P = .012) and LAVI (30.7 mL/m(2), SD = 8.76 vs 24.6 mL/m(2), SD = 6.57) (P = .002) than controls. Regression analysis showed that QTc and LAVI could correctly predict the presence of LPs in the 80.9% of the patients. CONCLUSIONS: β‐TM patients have a higher prevalence of a prolonged PR interval, atrial fibrillation, and LPs. Twelve‐lead and SAECG performance was feasible in all subjects and constitutes a readily available tool for assessing myocardial electrophysiological alterations in this patient group. John Wiley and Sons Inc. 2020-07-26 /pmc/articles/PMC7532271/ /pubmed/33024470 http://dx.doi.org/10.1002/joa3.12412 Text en © 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Patsourakos, Dimitrios
Gatzoulis, Konstantinos A.
Aggeli, Constantina
Delicou, Sophia
Dimitroglou, Yannis
Xydaki, Katerina
Toutouzas, Konstantinos
Androulakis, Aristeidis
Tousoulis, Dimitrios
Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
title Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
title_full Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
title_fullStr Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
title_full_unstemmed Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
title_short Twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
title_sort twelve‐lead and signal‐averaged electrocardiographic parameters among beta‐thalassemia major patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532271/
https://www.ncbi.nlm.nih.gov/pubmed/33024470
http://dx.doi.org/10.1002/joa3.12412
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