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In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae)
Babassu (Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532363/ https://www.ncbi.nlm.nih.gov/pubmed/33029179 http://dx.doi.org/10.1155/2020/8858291 |
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author | Santos, José Alex A. da Silva, José Wellinton dos Santos, Simone Maria Rodrigues, Maria de Fátima Silva, Camila Joyce A. da Silva, Márcia Vanusa Correia, Maria Tereza S. Albuquerque, Julianna F. C. Melo, Cristiane M. L. Silva, Teresinha G. Martins, René D. Aguiar Júnior, Francisco Carlos A. Ximenes, Rafael M. |
author_facet | Santos, José Alex A. da Silva, José Wellinton dos Santos, Simone Maria Rodrigues, Maria de Fátima Silva, Camila Joyce A. da Silva, Márcia Vanusa Correia, Maria Tereza S. Albuquerque, Julianna F. C. Melo, Cristiane M. L. Silva, Teresinha G. Martins, René D. Aguiar Júnior, Francisco Carlos A. Ximenes, Rafael M. |
author_sort | Santos, José Alex A. |
collection | PubMed |
description | Babassu (Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is used in culinary, as fuel, and mostly as medicinal oil for the treatment of skin wounds and inflammation. This study aimed to evaluate in vitro and in vivo the wound healing effects of babassu oil. In vitro, babassu oil increased the migration of L929 fibroblasts, inhibited the production of nitric oxide by LPS-stimulated peritoneal macrophages, and increased the levels of INF-γ and IL-6 cytokines production. In vivo, babassu oil accelerated the healing process in a full-thickness splinted wound model, by an increase in the fibroblasts number, blood vessels, and collagen deposition in the wounds. The babassu oil also increased the recruitment of inflammatory cells into the wound site and showed an anti-inflammatory effect in a chronic ear edema model, reducing ear thickness, epidermal hyperplasia, and myeloperoxidase activity. Thus, these data corroborate the use of babassu oil in folk medicine as a remedy to treat skin wounds. |
format | Online Article Text |
id | pubmed-7532363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75323632020-10-06 In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae) Santos, José Alex A. da Silva, José Wellinton dos Santos, Simone Maria Rodrigues, Maria de Fátima Silva, Camila Joyce A. da Silva, Márcia Vanusa Correia, Maria Tereza S. Albuquerque, Julianna F. C. Melo, Cristiane M. L. Silva, Teresinha G. Martins, René D. Aguiar Júnior, Francisco Carlos A. Ximenes, Rafael M. Evid Based Complement Alternat Med Research Article Babassu (Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is used in culinary, as fuel, and mostly as medicinal oil for the treatment of skin wounds and inflammation. This study aimed to evaluate in vitro and in vivo the wound healing effects of babassu oil. In vitro, babassu oil increased the migration of L929 fibroblasts, inhibited the production of nitric oxide by LPS-stimulated peritoneal macrophages, and increased the levels of INF-γ and IL-6 cytokines production. In vivo, babassu oil accelerated the healing process in a full-thickness splinted wound model, by an increase in the fibroblasts number, blood vessels, and collagen deposition in the wounds. The babassu oil also increased the recruitment of inflammatory cells into the wound site and showed an anti-inflammatory effect in a chronic ear edema model, reducing ear thickness, epidermal hyperplasia, and myeloperoxidase activity. Thus, these data corroborate the use of babassu oil in folk medicine as a remedy to treat skin wounds. Hindawi 2020-09-24 /pmc/articles/PMC7532363/ /pubmed/33029179 http://dx.doi.org/10.1155/2020/8858291 Text en Copyright © 2020 José Alex A. Santos et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Santos, José Alex A. da Silva, José Wellinton dos Santos, Simone Maria Rodrigues, Maria de Fátima Silva, Camila Joyce A. da Silva, Márcia Vanusa Correia, Maria Tereza S. Albuquerque, Julianna F. C. Melo, Cristiane M. L. Silva, Teresinha G. Martins, René D. Aguiar Júnior, Francisco Carlos A. Ximenes, Rafael M. In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae) |
title | In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae) |
title_full | In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae) |
title_fullStr | In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae) |
title_full_unstemmed | In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae) |
title_short | In Vitro and In Vivo Wound Healing and Anti-Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae) |
title_sort | in vitro and in vivo wound healing and anti-inflammatory activities of babassu oil (attalea speciosa mart. ex spreng., arecaceae) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532363/ https://www.ncbi.nlm.nih.gov/pubmed/33029179 http://dx.doi.org/10.1155/2020/8858291 |
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