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Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use
Methadone is a well-tolerated drug that has been used for pain control and the treatment of opioid addiction. However, some fatal cardiac side effects have been reported previously, including ventricular arrhythmia, stress cardiomyopathy, and coronary artery disease. We reported a middle-aged woman...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532395/ https://www.ncbi.nlm.nih.gov/pubmed/33029432 http://dx.doi.org/10.1155/2020/4504657 |
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author | Tam, Weng-Chio Lam, U-Po Mok, Toi-Meng Chang, Tou Ho, Wa De Brito Lima Evora, Mario Alberto |
author_facet | Tam, Weng-Chio Lam, U-Po Mok, Toi-Meng Chang, Tou Ho, Wa De Brito Lima Evora, Mario Alberto |
author_sort | Tam, Weng-Chio |
collection | PubMed |
description | Methadone is a well-tolerated drug that has been used for pain control and the treatment of opioid addiction. However, some fatal cardiac side effects have been reported previously, including ventricular arrhythmia, stress cardiomyopathy, and coronary artery disease. We reported a middle-aged woman receiving high-dose methadone whom was presented with QT prolongation and torsade de pointes. We replaced the methadone with benzodiazepine and gave lidocaine use simultaneously. Thus, QT interval was shortened within the normal limit. Methadone-induced torsade de pointes is a rare but serious event, and QT interval should be monitored periodically to prevent this fatal adverse event, especially some patients with high-dose methadone use. |
format | Online Article Text |
id | pubmed-7532395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75323952020-10-06 Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use Tam, Weng-Chio Lam, U-Po Mok, Toi-Meng Chang, Tou Ho, Wa De Brito Lima Evora, Mario Alberto Case Rep Cardiol Case Report Methadone is a well-tolerated drug that has been used for pain control and the treatment of opioid addiction. However, some fatal cardiac side effects have been reported previously, including ventricular arrhythmia, stress cardiomyopathy, and coronary artery disease. We reported a middle-aged woman receiving high-dose methadone whom was presented with QT prolongation and torsade de pointes. We replaced the methadone with benzodiazepine and gave lidocaine use simultaneously. Thus, QT interval was shortened within the normal limit. Methadone-induced torsade de pointes is a rare but serious event, and QT interval should be monitored periodically to prevent this fatal adverse event, especially some patients with high-dose methadone use. Hindawi 2020-09-23 /pmc/articles/PMC7532395/ /pubmed/33029432 http://dx.doi.org/10.1155/2020/4504657 Text en Copyright © 2020 Weng-Chio Tam et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Tam, Weng-Chio Lam, U-Po Mok, Toi-Meng Chang, Tou Ho, Wa De Brito Lima Evora, Mario Alberto Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use |
title | Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use |
title_full | Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use |
title_fullStr | Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use |
title_full_unstemmed | Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use |
title_short | Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use |
title_sort | polymorphic ventricular tachycardia associated with high-dose methadone use |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532395/ https://www.ncbi.nlm.nih.gov/pubmed/33029432 http://dx.doi.org/10.1155/2020/4504657 |
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