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HMGB1 Recruits TET2/AID/TDG to Induce DNA Demethylation in STAT3 Promoter in CD4(+) T Cells from aGVHD Patients

STAT3 is highly expressed in aGVHD CD4(+) T cells and plays a critical role in inducing or worsening aGVHD. In our preceding studies, DNA hypomethylation in STAT3 promoter was shown to cause high expression of STAT3 in aGVHD CD4(+) T cells, and the process could be modulated by HMGB1, but the underl...

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Detalles Bibliográficos
Autores principales:	Xu, Xuejun, Chen, Yan, Liu, Enyi, Fu, Bin, Hua, Juan, Chen, Xu, Xu, Yajing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532413/ https://www.ncbi.nlm.nih.gov/pubmed/33029541 http://dx.doi.org/10.1155/2020/7165230

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