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Positive association between metabolic syndrome and bone mineral density among Malaysians
Objectives: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that elevates the individual risk of cardiovascular diseases. These abnormalities are also known to alter bone remodelling. Therefore, MetS may be associated with osteoporosis. This study aims to determine the association...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532478/ https://www.ncbi.nlm.nih.gov/pubmed/33029101 http://dx.doi.org/10.7150/ijms.49030 |
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author | Chin, Kok-Yong Chan, Chin Yi Subramaniam, Shaanthana Muhammad, Norliza Fairus, Ahmad Ng, Pei Yuen Jamil, Nor Aini Aziz, Noorazah Abd Ima-Nirwana, Soelaiman Mohamed, Norazlina |
author_facet | Chin, Kok-Yong Chan, Chin Yi Subramaniam, Shaanthana Muhammad, Norliza Fairus, Ahmad Ng, Pei Yuen Jamil, Nor Aini Aziz, Noorazah Abd Ima-Nirwana, Soelaiman Mohamed, Norazlina |
author_sort | Chin, Kok-Yong |
collection | PubMed |
description | Objectives: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that elevates the individual risk of cardiovascular diseases. These abnormalities are also known to alter bone remodelling. Therefore, MetS may be associated with osteoporosis. This study aims to determine the association between MetS and its components and bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry (DXA) among Malaysians. Methods: 400 Malaysians aged ≥ 40 years (52.5% women) residing in Klang Valley, Malaysia, were recruited. Subjects' demographic and lifestyle details were collected using a questionnaire, and blood pressure and body anthropometry were measured. Subjects' lumbar spine and total hip BMD were measured by DXA. Their fasting blood was collected for blood glucose level and lipid profile analysis. Regression analysis was used to analyze the relationship between MetS or its components and BMD. Results: Subjects with MetS had higher BMD compared to subjects without MetS in models unadjusted for BMI (spine p=0.008; hip p<0.001). This difference was attenuated with BMI adjustment (spine p=0.625; hip p=0.478). Waist circumference was associated positively with BMD in models unadjusted for BMI (spine p=0.012; hip p<0.001), but the association became negative with BMI adjustment (spine p=0.044; hip p=0.021). Systolic blood pressure was associated positively with total hip BMD (p=0.019) but BMI adjustment attenuated the relationship (p=0.080). Triglyceride level was associated with osteoporosis in a fully adjusted model (p=0.001). Overall, MetS was associated with osteoporosis (p=0.019) but lifestyle (p=0.188) and BMI adjustment attenuated the relationship (p=0.904). Conclusion: MetS is positively associated with BMD, and this relationship is predominantly mediated by BMI. Although MetS is not a significant risk factor for osteoporosis, the inverse relationship between waist circumference, a marker of central obesity, and BMD highlights the need to prevent adiposity to improve metabolic and skeletal health. |
format | Online Article Text |
id | pubmed-7532478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-75324782020-10-06 Positive association between metabolic syndrome and bone mineral density among Malaysians Chin, Kok-Yong Chan, Chin Yi Subramaniam, Shaanthana Muhammad, Norliza Fairus, Ahmad Ng, Pei Yuen Jamil, Nor Aini Aziz, Noorazah Abd Ima-Nirwana, Soelaiman Mohamed, Norazlina Int J Med Sci Research Paper Objectives: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that elevates the individual risk of cardiovascular diseases. These abnormalities are also known to alter bone remodelling. Therefore, MetS may be associated with osteoporosis. This study aims to determine the association between MetS and its components and bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry (DXA) among Malaysians. Methods: 400 Malaysians aged ≥ 40 years (52.5% women) residing in Klang Valley, Malaysia, were recruited. Subjects' demographic and lifestyle details were collected using a questionnaire, and blood pressure and body anthropometry were measured. Subjects' lumbar spine and total hip BMD were measured by DXA. Their fasting blood was collected for blood glucose level and lipid profile analysis. Regression analysis was used to analyze the relationship between MetS or its components and BMD. Results: Subjects with MetS had higher BMD compared to subjects without MetS in models unadjusted for BMI (spine p=0.008; hip p<0.001). This difference was attenuated with BMI adjustment (spine p=0.625; hip p=0.478). Waist circumference was associated positively with BMD in models unadjusted for BMI (spine p=0.012; hip p<0.001), but the association became negative with BMI adjustment (spine p=0.044; hip p=0.021). Systolic blood pressure was associated positively with total hip BMD (p=0.019) but BMI adjustment attenuated the relationship (p=0.080). Triglyceride level was associated with osteoporosis in a fully adjusted model (p=0.001). Overall, MetS was associated with osteoporosis (p=0.019) but lifestyle (p=0.188) and BMI adjustment attenuated the relationship (p=0.904). Conclusion: MetS is positively associated with BMD, and this relationship is predominantly mediated by BMI. Although MetS is not a significant risk factor for osteoporosis, the inverse relationship between waist circumference, a marker of central obesity, and BMD highlights the need to prevent adiposity to improve metabolic and skeletal health. Ivyspring International Publisher 2020-09-16 /pmc/articles/PMC7532478/ /pubmed/33029101 http://dx.doi.org/10.7150/ijms.49030 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Chin, Kok-Yong Chan, Chin Yi Subramaniam, Shaanthana Muhammad, Norliza Fairus, Ahmad Ng, Pei Yuen Jamil, Nor Aini Aziz, Noorazah Abd Ima-Nirwana, Soelaiman Mohamed, Norazlina Positive association between metabolic syndrome and bone mineral density among Malaysians |
title | Positive association between metabolic syndrome and bone mineral density among Malaysians |
title_full | Positive association between metabolic syndrome and bone mineral density among Malaysians |
title_fullStr | Positive association between metabolic syndrome and bone mineral density among Malaysians |
title_full_unstemmed | Positive association between metabolic syndrome and bone mineral density among Malaysians |
title_short | Positive association between metabolic syndrome and bone mineral density among Malaysians |
title_sort | positive association between metabolic syndrome and bone mineral density among malaysians |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532478/ https://www.ncbi.nlm.nih.gov/pubmed/33029101 http://dx.doi.org/10.7150/ijms.49030 |
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