miR-552: an important post-transcriptional regulator that affects human cancer

MiR-552 is a small non-coding RNA located on chromosome 1p34.3, and its expression level is significantly up-regulated in tissues or cells of various tumors. miR-552 can target multiple genes. These targeted genes play important regulatory roles in biological processes such as gene transcription and...

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Detalles Bibliográficos
Autores principales: Zou, Yuhao, Zhao, Xin, Li, Yin, Duan, Shiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532495/
https://www.ncbi.nlm.nih.gov/pubmed/33033505
http://dx.doi.org/10.7150/jca.46613
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author Zou, Yuhao
Zhao, Xin
Li, Yin
Duan, Shiwei
author_facet Zou, Yuhao
Zhao, Xin
Li, Yin
Duan, Shiwei
author_sort Zou, Yuhao
collection PubMed
description MiR-552 is a small non-coding RNA located on chromosome 1p34.3, and its expression level is significantly up-regulated in tissues or cells of various tumors. miR-552 can target multiple genes. These targeted genes play important regulatory roles in biological processes such as gene transcription and translation, cell cycle progression, cell proliferation, apoptosis, cell migration, and invasion. Besides, miR-552 may affect the efficacy of various anticancer drugs by targeting genes such as TP53 and RUNX3. This review summarizes the biological functions and clinical expressions of miR-552 in human cancer. Our goal is to explore the potential value of miR-552 in the diagnosis, prognosis, and treatment of human cancer.
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spelling pubmed-75324952020-10-07 miR-552: an important post-transcriptional regulator that affects human cancer Zou, Yuhao Zhao, Xin Li, Yin Duan, Shiwei J Cancer Review MiR-552 is a small non-coding RNA located on chromosome 1p34.3, and its expression level is significantly up-regulated in tissues or cells of various tumors. miR-552 can target multiple genes. These targeted genes play important regulatory roles in biological processes such as gene transcription and translation, cell cycle progression, cell proliferation, apoptosis, cell migration, and invasion. Besides, miR-552 may affect the efficacy of various anticancer drugs by targeting genes such as TP53 and RUNX3. This review summarizes the biological functions and clinical expressions of miR-552 in human cancer. Our goal is to explore the potential value of miR-552 in the diagnosis, prognosis, and treatment of human cancer. Ivyspring International Publisher 2020-08-27 /pmc/articles/PMC7532495/ /pubmed/33033505 http://dx.doi.org/10.7150/jca.46613 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zou, Yuhao
Zhao, Xin
Li, Yin
Duan, Shiwei
miR-552: an important post-transcriptional regulator that affects human cancer
title miR-552: an important post-transcriptional regulator that affects human cancer
title_full miR-552: an important post-transcriptional regulator that affects human cancer
title_fullStr miR-552: an important post-transcriptional regulator that affects human cancer
title_full_unstemmed miR-552: an important post-transcriptional regulator that affects human cancer
title_short miR-552: an important post-transcriptional regulator that affects human cancer
title_sort mir-552: an important post-transcriptional regulator that affects human cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532495/
https://www.ncbi.nlm.nih.gov/pubmed/33033505
http://dx.doi.org/10.7150/jca.46613
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AT duanshiwei mir552animportantposttranscriptionalregulatorthataffectshumancancer

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