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Antiviral effect of baicalin on Marek’s disease virus in CEF cells
BACKGROUND: Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek’s disease virus (MDV)...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532598/ https://www.ncbi.nlm.nih.gov/pubmed/33008383 http://dx.doi.org/10.1186/s12917-020-02595-x |
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author | Yang, Fan Feng, Chun Yao, Yongxiu Qin, Aijian Shao, Hongxia Qian, Kun |
author_facet | Yang, Fan Feng, Chun Yao, Yongxiu Qin, Aijian Shao, Hongxia Qian, Kun |
author_sort | Yang, Fan |
collection | PubMed |
description | BACKGROUND: Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek’s disease virus (MDV) activities of baicalin in CEF cells. RESULTS: Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in MDV infected CEFs. CONCLUSIONS: These results demonstrate that baicalin could be a potential drug against MDV infection. |
format | Online Article Text |
id | pubmed-7532598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75325982020-10-05 Antiviral effect of baicalin on Marek’s disease virus in CEF cells Yang, Fan Feng, Chun Yao, Yongxiu Qin, Aijian Shao, Hongxia Qian, Kun BMC Vet Res Research Article BACKGROUND: Baicalin, the main metabolic component of Scutellaria baicalensis Georgi, has various pharmacological properties including anti-inflammatory, anti-oxidant, anti-apoptotic, anti-bactericidal and anti-viral. The purpose of this study was to investigate the anti-Marek’s disease virus (MDV) activities of baicalin in CEF cells. RESULTS: Here, we showed that baicalin could inhibit viral mRNA, protein levels and overall plaque formation in a time-dependent manner. We also found that baicalin could consistently inhibit MDV replication and directly affect the virus infectivity. Moreover, baicalin treatment has no effect on expression level of antiviral cytokine and inflammatory cytokines in MDV infected CEFs. CONCLUSIONS: These results demonstrate that baicalin could be a potential drug against MDV infection. BioMed Central 2020-10-02 /pmc/articles/PMC7532598/ /pubmed/33008383 http://dx.doi.org/10.1186/s12917-020-02595-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Yang, Fan Feng, Chun Yao, Yongxiu Qin, Aijian Shao, Hongxia Qian, Kun Antiviral effect of baicalin on Marek’s disease virus in CEF cells |
title | Antiviral effect of baicalin on Marek’s disease virus in CEF cells |
title_full | Antiviral effect of baicalin on Marek’s disease virus in CEF cells |
title_fullStr | Antiviral effect of baicalin on Marek’s disease virus in CEF cells |
title_full_unstemmed | Antiviral effect of baicalin on Marek’s disease virus in CEF cells |
title_short | Antiviral effect of baicalin on Marek’s disease virus in CEF cells |
title_sort | antiviral effect of baicalin on marek’s disease virus in cef cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532598/ https://www.ncbi.nlm.nih.gov/pubmed/33008383 http://dx.doi.org/10.1186/s12917-020-02595-x |
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