Cargando…

Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer

Rationale: Radioresistance remains the major cause of local relapse and distant metastasis in lung cancer. However, the underlying molecular mechanisms remain poorly defined. This study aimed to investigate the role and regulatory mechanism of Cyclin K in lung cancer radioresistance. Methods: Expres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yao, Guojun, Tang, Jing, Yang, Xijie, Zhao, Ye, Zhou, Rui, Meng, Rui, Zhang, Sheng, Dong, Xiaorong, Zhang, Tao, Yang, Kunyu, Wu, Gang, Xu, Shuangbing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532664/ https://www.ncbi.nlm.nih.gov/pubmed/33042275 http://dx.doi.org/10.7150/thno.42578

Ejemplares similares

UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance
por: Huang, Yumei, et al.
Publicado: (2020)

USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription
por: Jie, Xiaohua, et al.
Publicado: (2021)

S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer
por: Huang, Yumei, et al.
Publicado: (2018)

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma
por: Lu, Yanwei, et al.
Publicado: (2021)

CDP138 silencing inhibits TGF-β/Smad signaling to impair radioresistance and metastasis via GDF15 in lung cancer
por: Lu, Yanwei, et al.
Publicado: (2017)

Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer
por: Xu, Tie, et al.
Publicado: (2020)

Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer
por: Jie, Xiaohua, et al.
Publicado: (2022)

CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer
por: Xie, Jie, et al.
Publicado: (2018)

Cyclin K and cyclin D1b are oncogenic in myeloma cells
por: Marsaud, Véronique, et al.
Publicado: (2010)

Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signaling
por: Bernaudo, S, et al.
Publicado: (2016)

Erratum: Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signalling
por: Bernaudo, S, et al.
Publicado: (2016)

Too Much Cleavage of Cyclin E Promotes Breast Tumorigenesis
por: Loeb, Keith R., et al.
Publicado: (2012)

Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/β-catenin (cyclin D1) axis
por: Yang, Su-jin, et al.
Publicado: (2021)

CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization
por: Tung, Jai-Nien, et al.
Publicado: (2010)

β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis
por: Mirando, Anthony J, et al.
Publicado: (2010)

Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3
por: Zhou, Dong, et al.
Publicado: (2023)

MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin
por: Liu, X, et al.
Publicado: (2014)

Cyclin G2 Suppresses Estrogen-Mediated Osteogenesis through Inhibition of Wnt/β-Catenin Signaling
por: Gao, Jinlan, et al.
Publicado: (2014)

FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma
por: Xu, Yunhong, et al.
Publicado: (2023)

Activation of c-Myc and Cyclin D1 by JCV T-Antigen and β-Catenin in Colon Cancer
por: Ripple, Michael J., et al.
Publicado: (2014)

UBE2M promotes cell proliferation via the β-catenin/cyclin D1 signaling in hepatocellular carcinoma
por: Zhang, Guang-Cong, et al.
Publicado: (2020)

The gammaherpesvirus 68 viral cyclin facilitates expression of LANA
por: Niemeyer, Brian F., et al.
Publicado: (2021)

Cyclin C: The Story of a Non-Cycling Cyclin
por: Ježek, Jan, et al.
Publicado: (2019)

Coming of Age: Targeting Cyclin K in Cancers
por: Xiao, Yi, et al.
Publicado: (2023)

Porphyromonas gingivalis lipopolysaccharide enhances the proliferation of human periodontal ligament cells via upregulation of cyclin D1, cyclin A and cyclin B1
por: Lu, Jiajing, et al.
Publicado: (2022)

Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway
por: Wang, Zuoyun, et al.
Publicado: (2020)

Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt/β-catenin signaling pathway
por: Zheng, Wenwei, et al.
Publicado: (2017)

Phosphorylation of cyclin O, a novel cyclin family protein containing a cyclin-like domain, is involved in the activation of cyclin-dependent kinase 2
por: KIM, DO HYUNG, et al.
Publicado: (2014)

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis
por: Casimiro, Mathew C., et al.
Publicado: (2015)

Activation of the AKT/cyclin D1/Cdk4 survival signaling pathway in radioresistant cancer stem cells
por: Shimura, T, et al.
Publicado: (2012)

Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1
por: Ramakrishnan, Rajesh, et al.
Publicado: (2011)

Cyclins in aspergilli: Phylogenetic and functional analyses of group I cyclins
por: Paolillo, V., et al.
Publicado: (2018)

The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer
por: Javed, Aadil, et al.
Publicado: (2023)

Functional Differentiation of Cyclins and Cyclin-Dependent Kinases in Giardia lamblia
por: Kim, Juri, et al.
Publicado: (2023)

Active Component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, Attenuates Lung Tumorigenesis via Inhibitions of VEGF, Cyclin A, and Cyclin B Expressions
por: Tung, Yu-Tang, et al.
Publicado: (2013)

Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1
por: Moore, Jonathan D., et al.
Publicado: (1999)

Involvement of Cyclin K Posttranscriptional Regulation in the Formation of Artemia Diapause Cysts
por: Zhao, Yang, et al.
Publicado: (2012)

Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex
por: Zhang, Jingxiao, et al.
Publicado: (2018)

REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2 axis
por: Chen, Yunshang, et al.
Publicado: (2022)

miR-592 acts as an oncogene and promotes medullary thyroid cancer tumorigenesis by targeting cyclin-dependent kinase 8
por: Liu, Ting, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bjvimbu70eqic2phf5i0re9gi6