Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine receptor 2 (RyR2) control of neuronal hyperactiv...

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Detalles Bibliográficos
Autores principales: Yao, Jinjing, Sun, Bo, Institoris, Adam, Zhan, Xiaoqin, Guo, Wenting, Song, Zhenpeng, Liu, Yajing, Hiess, Florian, Boyce, Andrew K.J., Ni, Mingke, Wang, Ruiwu, ter Keurs, Henk, Back, Thomas G., Fill, Michael, Thompson, Roger J., Turner, Ray W., Gordon, Grant R., Chen, S.R. Wayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532726/
https://www.ncbi.nlm.nih.gov/pubmed/32966798
http://dx.doi.org/10.1016/j.celrep.2020.108169

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