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Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey

PURPOSE: This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19). METHODS: An international cross-sectional survey was administered to 2557 caregivers of children in 1...

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Autores principales: Goldman, Ran D., Marneni, Shashidhar R., Seiler, Michelle, Brown, Julie C., Klein, Eileen J., Cotanda, Cristina Parra, Gelernter, Renana, Yan, Tyler D., Hoeffe, Julia, Davis, Adrienne L., Griffiths, Mark A., Hall, Jeanine E., Gualco, Gianluca, Mater, Ahmed, Manzano, Sergio, Thompson, Graham C., Ahmed, Sara, Ali, Samina, Shimizu, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532744/
https://www.ncbi.nlm.nih.gov/pubmed/33067013
http://dx.doi.org/10.1016/j.clinthera.2020.09.012
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author Goldman, Ran D.
Marneni, Shashidhar R.
Seiler, Michelle
Brown, Julie C.
Klein, Eileen J.
Cotanda, Cristina Parra
Gelernter, Renana
Yan, Tyler D.
Hoeffe, Julia
Davis, Adrienne L.
Griffiths, Mark A.
Hall, Jeanine E.
Gualco, Gianluca
Mater, Ahmed
Manzano, Sergio
Thompson, Graham C.
Ahmed, Sara
Ali, Samina
Shimizu, Naoki
author_facet Goldman, Ran D.
Marneni, Shashidhar R.
Seiler, Michelle
Brown, Julie C.
Klein, Eileen J.
Cotanda, Cristina Parra
Gelernter, Renana
Yan, Tyler D.
Hoeffe, Julia
Davis, Adrienne L.
Griffiths, Mark A.
Hall, Jeanine E.
Gualco, Gianluca
Mater, Ahmed
Manzano, Sergio
Thompson, Graham C.
Ahmed, Sara
Ali, Samina
Shimizu, Naoki
author_sort Goldman, Ran D.
collection PubMed
description PURPOSE: This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19). METHODS: An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine–approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann–Whitney U test for comparing non–normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ(2) or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of <0.05 was considered significant. FINDINGS: Almost half (1101/2557; 43%) of caregivers reported that they were willing to accept less rigorous testing and postresearch approval of a new COVID-19 vaccine. Independent factors associated with caregivers' willingness to accept expedited COVID-19 vaccine research included having children who were up to date on the vaccination schedule (odds ratio [OR] = 1.72; 95% CI, 1.29–2.31), caregivers' concern about having had COVID-19 themselves at the time of survey completion in the ED (OR = 1.1; 95% CI, 1.05–1.16), and caregivers' intent to have their children vaccinated against COVID-19 if a vaccine were to become available (OR = 1.84; 95% CI, 1.54–2.21). Compared with fathers, mothers completing the survey were less likely to approve of changes in the vaccine-development process (OR = 0.641; 95% CI, 0.529–0.775). IMPLICATIONS: Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. As a part of an effort to increase acceptance and uptake of a new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers' attitudes toward the approval of a vaccine and consult them appropriately.
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spelling pubmed-75327442020-10-05 Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey Goldman, Ran D. Marneni, Shashidhar R. Seiler, Michelle Brown, Julie C. Klein, Eileen J. Cotanda, Cristina Parra Gelernter, Renana Yan, Tyler D. Hoeffe, Julia Davis, Adrienne L. Griffiths, Mark A. Hall, Jeanine E. Gualco, Gianluca Mater, Ahmed Manzano, Sergio Thompson, Graham C. Ahmed, Sara Ali, Samina Shimizu, Naoki Clin Ther Original Research PURPOSE: This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19). METHODS: An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine–approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann–Whitney U test for comparing non–normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ(2) or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of <0.05 was considered significant. FINDINGS: Almost half (1101/2557; 43%) of caregivers reported that they were willing to accept less rigorous testing and postresearch approval of a new COVID-19 vaccine. Independent factors associated with caregivers' willingness to accept expedited COVID-19 vaccine research included having children who were up to date on the vaccination schedule (odds ratio [OR] = 1.72; 95% CI, 1.29–2.31), caregivers' concern about having had COVID-19 themselves at the time of survey completion in the ED (OR = 1.1; 95% CI, 1.05–1.16), and caregivers' intent to have their children vaccinated against COVID-19 if a vaccine were to become available (OR = 1.84; 95% CI, 1.54–2.21). Compared with fathers, mothers completing the survey were less likely to approve of changes in the vaccine-development process (OR = 0.641; 95% CI, 0.529–0.775). IMPLICATIONS: Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. As a part of an effort to increase acceptance and uptake of a new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers' attitudes toward the approval of a vaccine and consult them appropriately. Elsevier Inc. 2020-11 2020-10-03 /pmc/articles/PMC7532744/ /pubmed/33067013 http://dx.doi.org/10.1016/j.clinthera.2020.09.012 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Research
Goldman, Ran D.
Marneni, Shashidhar R.
Seiler, Michelle
Brown, Julie C.
Klein, Eileen J.
Cotanda, Cristina Parra
Gelernter, Renana
Yan, Tyler D.
Hoeffe, Julia
Davis, Adrienne L.
Griffiths, Mark A.
Hall, Jeanine E.
Gualco, Gianluca
Mater, Ahmed
Manzano, Sergio
Thompson, Graham C.
Ahmed, Sara
Ali, Samina
Shimizu, Naoki
Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
title Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
title_full Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
title_fullStr Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
title_full_unstemmed Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
title_short Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey
title_sort caregivers' willingness to accept expedited vaccine research during the covid-19 pandemic: a cross-sectional survey
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532744/
https://www.ncbi.nlm.nih.gov/pubmed/33067013
http://dx.doi.org/10.1016/j.clinthera.2020.09.012
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