Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach

Prenatal COVID infection is one of the worst affected and least attended aspects of the COVID-19 disease. Like other coronaviruses, CoV2 infection is anticipated to affect fetal development by maternal inflammatory response on the fetus and placenta. Studies showed that higher prenatal choline level...

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Detalles Bibliográficos
Autores principales: Chowdhury, Papia, Pathak, Pustak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532804/
https://www.ncbi.nlm.nih.gov/pubmed/33041350
http://dx.doi.org/10.1016/j.cplett.2020.138057
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author Chowdhury, Papia
Pathak, Pustak
author_facet Chowdhury, Papia
Pathak, Pustak
author_sort Chowdhury, Papia
collection PubMed
description Prenatal COVID infection is one of the worst affected and least attended aspects of the COVID-19 disease. Like other coronaviruses, CoV2 infection is anticipated to affect fetal development by maternal inflammatory response on the fetus and placenta. Studies showed that higher prenatal choline level in mother’s body can safeguard the developing brain of the fetus from the adverse effects of CoV2 infection. Choline is commonly used as food supplement. By virtual screening, molecular docking and molecular dynamics techniques, we have established a strong inhibitory possibility of choline for SARS 3CL(pro) protease which may provide a lead for prenatal COVID-19 treatment.
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spelling pubmed-75328042020-10-05 Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach Chowdhury, Papia Pathak, Pustak Chem Phys Lett Research Paper Prenatal COVID infection is one of the worst affected and least attended aspects of the COVID-19 disease. Like other coronaviruses, CoV2 infection is anticipated to affect fetal development by maternal inflammatory response on the fetus and placenta. Studies showed that higher prenatal choline level in mother’s body can safeguard the developing brain of the fetus from the adverse effects of CoV2 infection. Choline is commonly used as food supplement. By virtual screening, molecular docking and molecular dynamics techniques, we have established a strong inhibitory possibility of choline for SARS 3CL(pro) protease which may provide a lead for prenatal COVID-19 treatment. Elsevier B.V. 2020-12-16 2020-10-03 /pmc/articles/PMC7532804/ /pubmed/33041350 http://dx.doi.org/10.1016/j.cplett.2020.138057 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Research Paper
Chowdhury, Papia
Pathak, Pustak
Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach
title Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach
title_full Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach
title_fullStr Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach
title_full_unstemmed Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach
title_short Neuroprotective immunity by essential nutrient “Choline” for the prevention of SARS CoV2 infections: An in silico study by molecular dynamics approach
title_sort neuroprotective immunity by essential nutrient “choline” for the prevention of sars cov2 infections: an in silico study by molecular dynamics approach
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532804/
https://www.ncbi.nlm.nih.gov/pubmed/33041350
http://dx.doi.org/10.1016/j.cplett.2020.138057
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AT pathakpustak neuroprotectiveimmunitybyessentialnutrientcholineforthepreventionofsarscov2infectionsaninsilicostudybymoleculardynamicsapproach

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