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Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia
INTRODUCTION: Asymptomatic bacteriuria (ASB) is the presence of bacteria in significant quantity in the absence of signs and symptoms of urinary tract infection (UTI). ASB, if it occurs during pregnancy, can cause serious complications both among fetus and pregnant women. OBJECTIVE: The aim of this...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532909/ https://www.ncbi.nlm.nih.gov/pubmed/33061397 http://dx.doi.org/10.2147/TCRM.S267101 |
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author | Wabe, Yasin Awol Reda, Dawit Yihdego Abreham, Estifanos Tsige Gobene, Degeuf Beyene Ali, Musa Mohammed |
author_facet | Wabe, Yasin Awol Reda, Dawit Yihdego Abreham, Estifanos Tsige Gobene, Degeuf Beyene Ali, Musa Mohammed |
author_sort | Wabe, Yasin Awol |
collection | PubMed |
description | INTRODUCTION: Asymptomatic bacteriuria (ASB) is the presence of bacteria in significant quantity in the absence of signs and symptoms of urinary tract infection (UTI). ASB, if it occurs during pregnancy, can cause serious complications both among fetus and pregnant women. OBJECTIVE: The aim of this study was to determine the prevalence of ASB, its associated factors, and antimicrobial susceptibility profile of bacterial isolates among pregnant women. METHODS: A cross-sectional study was conducted from July to September 2019 among 290 pregnant women at Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Clean-catch midstream urine specimens were collected using sterile containers and cultured on MacConkey agar and sheep blood agar to isolate bacteria. Socio-demographic and obstetric data were collected using a structured questionnaire. Data were analyzed by SPSS version 22. The association between ASB and risk factors was assessed using logistic regressions. A p-value ≤0.05 was considered as a cut point to determine the significant association. RESULTS: From 290 study participants, 16.9% with 95 CI [13.1, 21.5] were positive for ASB. The predominant bacteria were Escherichia coli (43%) and Staphylococcus aureus (20%). Majority of E. coli (91.0%) were susceptible to nitrofurantoin and gentamycin; most of them were resistant to amoxicillin (86.4%) and cotrimoxazole (77.7%). The proportion of multi-drug resistance (MDR) isolates was 57.1%. Previous infection with UTI, previous history of catheterization, and natural abortion were significantly associated with ASB. CONCLUSION: In the study area, ASB is prevalent in the study area indicating the importance of screening of ASB and possible treatment to prevent its consequences. |
format | Online Article Text |
id | pubmed-7532909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-75329092020-10-14 Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia Wabe, Yasin Awol Reda, Dawit Yihdego Abreham, Estifanos Tsige Gobene, Degeuf Beyene Ali, Musa Mohammed Ther Clin Risk Manag Original Research INTRODUCTION: Asymptomatic bacteriuria (ASB) is the presence of bacteria in significant quantity in the absence of signs and symptoms of urinary tract infection (UTI). ASB, if it occurs during pregnancy, can cause serious complications both among fetus and pregnant women. OBJECTIVE: The aim of this study was to determine the prevalence of ASB, its associated factors, and antimicrobial susceptibility profile of bacterial isolates among pregnant women. METHODS: A cross-sectional study was conducted from July to September 2019 among 290 pregnant women at Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Clean-catch midstream urine specimens were collected using sterile containers and cultured on MacConkey agar and sheep blood agar to isolate bacteria. Socio-demographic and obstetric data were collected using a structured questionnaire. Data were analyzed by SPSS version 22. The association between ASB and risk factors was assessed using logistic regressions. A p-value ≤0.05 was considered as a cut point to determine the significant association. RESULTS: From 290 study participants, 16.9% with 95 CI [13.1, 21.5] were positive for ASB. The predominant bacteria were Escherichia coli (43%) and Staphylococcus aureus (20%). Majority of E. coli (91.0%) were susceptible to nitrofurantoin and gentamycin; most of them were resistant to amoxicillin (86.4%) and cotrimoxazole (77.7%). The proportion of multi-drug resistance (MDR) isolates was 57.1%. Previous infection with UTI, previous history of catheterization, and natural abortion were significantly associated with ASB. CONCLUSION: In the study area, ASB is prevalent in the study area indicating the importance of screening of ASB and possible treatment to prevent its consequences. Dove 2020-09-29 /pmc/articles/PMC7532909/ /pubmed/33061397 http://dx.doi.org/10.2147/TCRM.S267101 Text en © 2020 Wabe et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Wabe, Yasin Awol Reda, Dawit Yihdego Abreham, Estifanos Tsige Gobene, Degeuf Beyene Ali, Musa Mohammed Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia |
title | Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia |
title_full | Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia |
title_fullStr | Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia |
title_full_unstemmed | Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia |
title_short | Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia |
title_sort | prevalence of asymptomatic bacteriuria, associated factors and antimicrobial susceptibility profile of bacteria among pregnant women attending saint paul’s hospital millennium medical college, addis ababa, ethiopia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532909/ https://www.ncbi.nlm.nih.gov/pubmed/33061397 http://dx.doi.org/10.2147/TCRM.S267101 |
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