What turns CREB on? And off? And why does it matter?

Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of C...

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Autores principales: Steven, André, Friedrich, Michael, Jank, Paul, Heimer, Nadine, Budczies, Jan, Denkert, Carsten, Seliger, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532970/
https://www.ncbi.nlm.nih.gov/pubmed/32347317
http://dx.doi.org/10.1007/s00018-020-03525-8
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author Steven, André
Friedrich, Michael
Jank, Paul
Heimer, Nadine
Budczies, Jan
Denkert, Carsten
Seliger, Barbara
author_facet Steven, André
Friedrich, Michael
Jank, Paul
Heimer, Nadine
Budczies, Jan
Denkert, Carsten
Seliger, Barbara
author_sort Steven, André
collection PubMed
description Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00018-020-03525-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-75329702020-10-19 What turns CREB on? And off? And why does it matter? Steven, André Friedrich, Michael Jank, Paul Heimer, Nadine Budczies, Jan Denkert, Carsten Seliger, Barbara Cell Mol Life Sci Review Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00018-020-03525-8) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-04-28 2020 /pmc/articles/PMC7532970/ /pubmed/32347317 http://dx.doi.org/10.1007/s00018-020-03525-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Steven, André
Friedrich, Michael
Jank, Paul
Heimer, Nadine
Budczies, Jan
Denkert, Carsten
Seliger, Barbara
What turns CREB on? And off? And why does it matter?
title What turns CREB on? And off? And why does it matter?
title_full What turns CREB on? And off? And why does it matter?
title_fullStr What turns CREB on? And off? And why does it matter?
title_full_unstemmed What turns CREB on? And off? And why does it matter?
title_short What turns CREB on? And off? And why does it matter?
title_sort what turns creb on? and off? and why does it matter?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532970/
https://www.ncbi.nlm.nih.gov/pubmed/32347317
http://dx.doi.org/10.1007/s00018-020-03525-8
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