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Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy
PURPOSE: In the present study, the salivary melatonin secretion in the hypoxic ischemic encephalopathy (HIE) children was measured. The logit model was fitted to the data to obtain the salivary dim light melatonin onsets (DLMOs), and the results were compared with the values estimated from the class...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533010/ https://www.ncbi.nlm.nih.gov/pubmed/33061967 http://dx.doi.org/10.1155/2020/6209841 |
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author | Kapek, Łukasz Paprocka, Justyna Kijonka, Marek Zych, Maria Emich-Widera, Ewa Rzepka-Migut, Beata Borys, Damian Kaczmarczyk-Sedlak, Ilona Sokół, Maria |
author_facet | Kapek, Łukasz Paprocka, Justyna Kijonka, Marek Zych, Maria Emich-Widera, Ewa Rzepka-Migut, Beata Borys, Damian Kaczmarczyk-Sedlak, Ilona Sokół, Maria |
author_sort | Kapek, Łukasz |
collection | PubMed |
description | PURPOSE: In the present study, the salivary melatonin secretion in the hypoxic ischemic encephalopathy (HIE) children was measured. The logit model was fitted to the data to obtain the salivary dim light melatonin onsets (DLMOs), and the results were compared with the values estimated from the classic threshold method with a linear interpolation and those previously published for the blood measurements. MATERIALS AND METHODS: 9 patients suffering from HIE aged from 65 to 80 months were included in the study. The melatonin levels were assessed by a radioimmunoassay (RIA). The diurnal melatonin secretion was estimated using a nonlinear least squares method. Student's t-test and the Mann–Whitney U test were used for the comparisons of the obtained parameters. RESULTS: The circadian profiles of the melatonin secretion for both calculation methods do not differ statistically. The DLMO parameters obtained in the blood and saliva samples in children with hypoxic ischemic encephalopathy were similar. |
format | Online Article Text |
id | pubmed-7533010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75330102020-10-13 Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy Kapek, Łukasz Paprocka, Justyna Kijonka, Marek Zych, Maria Emich-Widera, Ewa Rzepka-Migut, Beata Borys, Damian Kaczmarczyk-Sedlak, Ilona Sokół, Maria Int J Endocrinol Research Article PURPOSE: In the present study, the salivary melatonin secretion in the hypoxic ischemic encephalopathy (HIE) children was measured. The logit model was fitted to the data to obtain the salivary dim light melatonin onsets (DLMOs), and the results were compared with the values estimated from the classic threshold method with a linear interpolation and those previously published for the blood measurements. MATERIALS AND METHODS: 9 patients suffering from HIE aged from 65 to 80 months were included in the study. The melatonin levels were assessed by a radioimmunoassay (RIA). The diurnal melatonin secretion was estimated using a nonlinear least squares method. Student's t-test and the Mann–Whitney U test were used for the comparisons of the obtained parameters. RESULTS: The circadian profiles of the melatonin secretion for both calculation methods do not differ statistically. The DLMO parameters obtained in the blood and saliva samples in children with hypoxic ischemic encephalopathy were similar. Hindawi 2020-09-25 /pmc/articles/PMC7533010/ /pubmed/33061967 http://dx.doi.org/10.1155/2020/6209841 Text en Copyright © 2020 Łukasz Kapek et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kapek, Łukasz Paprocka, Justyna Kijonka, Marek Zych, Maria Emich-Widera, Ewa Rzepka-Migut, Beata Borys, Damian Kaczmarczyk-Sedlak, Ilona Sokół, Maria Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy |
title | Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy |
title_full | Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy |
title_fullStr | Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy |
title_full_unstemmed | Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy |
title_short | Circadian Profile of Salivary Melatonin Secretion in Hypoxic Ischemic Encephalopathy |
title_sort | circadian profile of salivary melatonin secretion in hypoxic ischemic encephalopathy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533010/ https://www.ncbi.nlm.nih.gov/pubmed/33061967 http://dx.doi.org/10.1155/2020/6209841 |
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