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Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects

Spinal cord injury (SCI) is a structural event with devastating consequences worldwide. Due to the limited intrinsic regenerative capacity of the spinal cord in adults, the neural restoration after SCI is difficult. Acupuncture is effective for SCI-induced neurologic deficits, and the potential mech...

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Autores principales: Tang, Huiling, Guo, Yi, Zhao, Yadan, Wang, Songtao, Wang, Jiaqi, Li, Wei, Qin, Siru, Gong, Yinan, Fan, Wen, Chen, Zelin, Guo, Yongming, Xu, Zhifang, Fang, Yuxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533022/
https://www.ncbi.nlm.nih.gov/pubmed/33061954
http://dx.doi.org/10.1155/2020/8890655
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author Tang, Huiling
Guo, Yi
Zhao, Yadan
Wang, Songtao
Wang, Jiaqi
Li, Wei
Qin, Siru
Gong, Yinan
Fan, Wen
Chen, Zelin
Guo, Yongming
Xu, Zhifang
Fang, Yuxin
author_facet Tang, Huiling
Guo, Yi
Zhao, Yadan
Wang, Songtao
Wang, Jiaqi
Li, Wei
Qin, Siru
Gong, Yinan
Fan, Wen
Chen, Zelin
Guo, Yongming
Xu, Zhifang
Fang, Yuxin
author_sort Tang, Huiling
collection PubMed
description Spinal cord injury (SCI) is a structural event with devastating consequences worldwide. Due to the limited intrinsic regenerative capacity of the spinal cord in adults, the neural restoration after SCI is difficult. Acupuncture is effective for SCI-induced neurologic deficits, and the potential mechanisms responsible for its effects involve neural protection by the inhibition of inflammation, oxidation, and apoptosis. Moreover, acupuncture promotes neural regeneration and axon sprouting by activating multiple cellular signal transduction pathways, such as the Wnt, Notch, and Rho/Rho kinase (ROCK) pathways. Several studies have demonstrated that the efficacy of combining acupuncture with mesenchymal stem cells (MSCs) transplantation is superior to either procedure alone. The advantage of the combined treatment is dependent on the ability of acupuncture to enhance the survival of MSCs, promote their differentiation into neurons, and facilitate targeted migration of MSCs to the spinal cord. Additionally, the differentiation of MSCs into neurons overcomes the problem of the shortage of endogenous neural stem cells (NSCs) in the acupuncture-treated SCI patients. Therefore, the combination of acupuncture and MSCs transplantation could become a novel and effective strategy for the treatment of SCI. Such a possibility needs to be verified by basic and clinical research.
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spelling pubmed-75330222020-10-13 Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects Tang, Huiling Guo, Yi Zhao, Yadan Wang, Songtao Wang, Jiaqi Li, Wei Qin, Siru Gong, Yinan Fan, Wen Chen, Zelin Guo, Yongming Xu, Zhifang Fang, Yuxin Neural Plast Review Article Spinal cord injury (SCI) is a structural event with devastating consequences worldwide. Due to the limited intrinsic regenerative capacity of the spinal cord in adults, the neural restoration after SCI is difficult. Acupuncture is effective for SCI-induced neurologic deficits, and the potential mechanisms responsible for its effects involve neural protection by the inhibition of inflammation, oxidation, and apoptosis. Moreover, acupuncture promotes neural regeneration and axon sprouting by activating multiple cellular signal transduction pathways, such as the Wnt, Notch, and Rho/Rho kinase (ROCK) pathways. Several studies have demonstrated that the efficacy of combining acupuncture with mesenchymal stem cells (MSCs) transplantation is superior to either procedure alone. The advantage of the combined treatment is dependent on the ability of acupuncture to enhance the survival of MSCs, promote their differentiation into neurons, and facilitate targeted migration of MSCs to the spinal cord. Additionally, the differentiation of MSCs into neurons overcomes the problem of the shortage of endogenous neural stem cells (NSCs) in the acupuncture-treated SCI patients. Therefore, the combination of acupuncture and MSCs transplantation could become a novel and effective strategy for the treatment of SCI. Such a possibility needs to be verified by basic and clinical research. Hindawi 2020-09-25 /pmc/articles/PMC7533022/ /pubmed/33061954 http://dx.doi.org/10.1155/2020/8890655 Text en Copyright © 2020 Huiling Tang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tang, Huiling
Guo, Yi
Zhao, Yadan
Wang, Songtao
Wang, Jiaqi
Li, Wei
Qin, Siru
Gong, Yinan
Fan, Wen
Chen, Zelin
Guo, Yongming
Xu, Zhifang
Fang, Yuxin
Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
title Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
title_full Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
title_fullStr Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
title_full_unstemmed Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
title_short Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects
title_sort effects and mechanisms of acupuncture combined with mesenchymal stem cell transplantation on neural recovery after spinal cord injury: progress and prospects
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533022/
https://www.ncbi.nlm.nih.gov/pubmed/33061954
http://dx.doi.org/10.1155/2020/8890655
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