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Qualification and application of liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling

Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied for the determination of carisbamate in rat plasma to sup...

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Detalles Bibliográficos
Autores principales:	Lee, Byeong ill, Lim, Jeong-hyeon, Park, Min-Ho, Shin, Seok-Ho, Byeon, Jin-Ju, Choi, Jang-mi, Park, Seo-jin, Park, Min-jae, Park, Yuri, Shin, Young G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Clinical Pharmacology and Therapeutics 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533164/ https://www.ncbi.nlm.nih.gov/pubmed/33062628 http://dx.doi.org/10.12793/tcp.2020.28.e15

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