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Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones
There is a pressing need to improve the efficiency of drug development, and nowhere is that need more clear than in the case of neglected diseases like malaria. The peculiarities of pyrimidine metabolism in Plasmodium species make inhibition of dihydroorotate dehydrogenase (DHODH) an attractive targ...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533260/ https://www.ncbi.nlm.nih.gov/pubmed/32833084 http://dx.doi.org/10.1007/s10822-020-00333-x |