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Respiratory dysfunction in Parkinson's disease: a narrative review
The presence of respiratory symptoms in Parkinson's disease (PD) has been known since the first description of the disease, even though the prevalence and incidence of these disturbances are not well defined. Several causes have been reported, comprising obstructive and restrictive pulmonary di...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533305/ https://www.ncbi.nlm.nih.gov/pubmed/33043046 http://dx.doi.org/10.1183/23120541.00165-2020 |
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author | D'Arrigo, Andrea Floro, Stefano Bartesaghi, Francesca Casellato, Chiara Sferrazza Papa, Giuseppe Francesco Centanni, Stefano Priori, Alberto Bocci, Tommaso |
author_facet | D'Arrigo, Andrea Floro, Stefano Bartesaghi, Francesca Casellato, Chiara Sferrazza Papa, Giuseppe Francesco Centanni, Stefano Priori, Alberto Bocci, Tommaso |
author_sort | D'Arrigo, Andrea |
collection | PubMed |
description | The presence of respiratory symptoms in Parkinson's disease (PD) has been known since the first description of the disease, even though the prevalence and incidence of these disturbances are not well defined. Several causes have been reported, comprising obstructive and restrictive pulmonary disease and changes in the central ventilatory control, and different pathogenetic mechanisms have been postulated accordingly. In our review, we encompass the current knowledge about respiratory abnormalities in PD, as well as the impact of anti-Parkinsonian drugs as either risk or protective factors. A description of putative pathogenetic mechanisms is also provided, and possible treatments are discussed, focusing on the importance of recognising and treating respiratory symptoms as a key manifestation of the disease itself. A brief description of respiratory dysfunctions in atypical Parkinsonism, especially α-synucleinopathies, is also provided. |
format | Online Article Text |
id | pubmed-7533305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-75333052020-10-09 Respiratory dysfunction in Parkinson's disease: a narrative review D'Arrigo, Andrea Floro, Stefano Bartesaghi, Francesca Casellato, Chiara Sferrazza Papa, Giuseppe Francesco Centanni, Stefano Priori, Alberto Bocci, Tommaso ERJ Open Res Review The presence of respiratory symptoms in Parkinson's disease (PD) has been known since the first description of the disease, even though the prevalence and incidence of these disturbances are not well defined. Several causes have been reported, comprising obstructive and restrictive pulmonary disease and changes in the central ventilatory control, and different pathogenetic mechanisms have been postulated accordingly. In our review, we encompass the current knowledge about respiratory abnormalities in PD, as well as the impact of anti-Parkinsonian drugs as either risk or protective factors. A description of putative pathogenetic mechanisms is also provided, and possible treatments are discussed, focusing on the importance of recognising and treating respiratory symptoms as a key manifestation of the disease itself. A brief description of respiratory dysfunctions in atypical Parkinsonism, especially α-synucleinopathies, is also provided. European Respiratory Society 2020-10-05 /pmc/articles/PMC7533305/ /pubmed/33043046 http://dx.doi.org/10.1183/23120541.00165-2020 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Review D'Arrigo, Andrea Floro, Stefano Bartesaghi, Francesca Casellato, Chiara Sferrazza Papa, Giuseppe Francesco Centanni, Stefano Priori, Alberto Bocci, Tommaso Respiratory dysfunction in Parkinson's disease: a narrative review |
title | Respiratory dysfunction in Parkinson's disease: a narrative review |
title_full | Respiratory dysfunction in Parkinson's disease: a narrative review |
title_fullStr | Respiratory dysfunction in Parkinson's disease: a narrative review |
title_full_unstemmed | Respiratory dysfunction in Parkinson's disease: a narrative review |
title_short | Respiratory dysfunction in Parkinson's disease: a narrative review |
title_sort | respiratory dysfunction in parkinson's disease: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533305/ https://www.ncbi.nlm.nih.gov/pubmed/33043046 http://dx.doi.org/10.1183/23120541.00165-2020 |
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