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Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children

INTRODUCTION: Red cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to be associated both with obstructive sleep apnoea (OSA) and wi...

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Autores principales: Morell-Garcia, Daniel, Toledo-Pons, Núria, Sanchis, Pilar, Bauça, Josep Miquel, Sánchez, José María, Peña-Zarza, José, Giménez, Paloma, Pierola, Javier, de la Peña-Bravo, Mónica, Alonso-Fernández, Alberto, Barceló, Antònia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533379/
https://www.ncbi.nlm.nih.gov/pubmed/33043053
http://dx.doi.org/10.1183/23120541.00278-2019
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author Morell-Garcia, Daniel
Toledo-Pons, Núria
Sanchis, Pilar
Bauça, Josep Miquel
Sánchez, José María
Peña-Zarza, José
Giménez, Paloma
Pierola, Javier
de la Peña-Bravo, Mónica
Alonso-Fernández, Alberto
Barceló, Antònia
author_facet Morell-Garcia, Daniel
Toledo-Pons, Núria
Sanchis, Pilar
Bauça, Josep Miquel
Sánchez, José María
Peña-Zarza, José
Giménez, Paloma
Pierola, Javier
de la Peña-Bravo, Mónica
Alonso-Fernández, Alberto
Barceló, Antònia
author_sort Morell-Garcia, Daniel
collection PubMed
description INTRODUCTION: Red cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to be associated both with obstructive sleep apnoea (OSA) and with an increase in cardiovascular mortality. The aim of this study was to determine whether RDW is a potential biomarker for screening children with moderate–severe OSA. METHODS: An observational study in snoring patients was performed. All patients underwent a sleep study and were classified either as simple snorers (apnoea–hypopnoea index (AHI) <1 event·h(−1)) or as patients with OSA (mild AHI ≥1 to <5 events·h(−1); moderate–severe AHI ≥5 events·h(−1)). Blood analyses (complete blood count and C-reactive protein) were performed for every individual. RESULTS: A total of 175 individuals were recruited. The mean age was 8.3±3.6 years. Correlation studies between RDW and several sleep-related parameters showed negative significant associations with minimum oxygen saturation, and positive significant associations with oxygen desaturation index (≥3% and ≥4%), AHI and the arousal index. A predictive model for paediatric severe OSA (AHI ≥5 events·h(−1)) was found based on mean corpuscular haemoglobin concentration (MCHC) <34.9 g·dL(−1) and RDW >13.1% values, adjusting for body mass index z-score and age (area under the curve 0.657; p=0.004). In addition, differences were found in eosinophil count and C-reactive protein concentrations among the three subgroups. CONCLUSIONS: In children, RDW stands out as a biomarker associated with the severity of OSA. The use of RDW and MCHC could be a simple but useful tool for the severity prediction of paediatric OSA in snoring patients.
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spelling pubmed-75333792020-10-09 Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children Morell-Garcia, Daniel Toledo-Pons, Núria Sanchis, Pilar Bauça, Josep Miquel Sánchez, José María Peña-Zarza, José Giménez, Paloma Pierola, Javier de la Peña-Bravo, Mónica Alonso-Fernández, Alberto Barceló, Antònia ERJ Open Res Original Articles INTRODUCTION: Red cell distribution width (RDW) is a parameter included in the complete blood count which informs about the size of the circulating red blood cell population and its distribution. In adults, an increase in RDW was shown to be associated both with obstructive sleep apnoea (OSA) and with an increase in cardiovascular mortality. The aim of this study was to determine whether RDW is a potential biomarker for screening children with moderate–severe OSA. METHODS: An observational study in snoring patients was performed. All patients underwent a sleep study and were classified either as simple snorers (apnoea–hypopnoea index (AHI) <1 event·h(−1)) or as patients with OSA (mild AHI ≥1 to <5 events·h(−1); moderate–severe AHI ≥5 events·h(−1)). Blood analyses (complete blood count and C-reactive protein) were performed for every individual. RESULTS: A total of 175 individuals were recruited. The mean age was 8.3±3.6 years. Correlation studies between RDW and several sleep-related parameters showed negative significant associations with minimum oxygen saturation, and positive significant associations with oxygen desaturation index (≥3% and ≥4%), AHI and the arousal index. A predictive model for paediatric severe OSA (AHI ≥5 events·h(−1)) was found based on mean corpuscular haemoglobin concentration (MCHC) <34.9 g·dL(−1) and RDW >13.1% values, adjusting for body mass index z-score and age (area under the curve 0.657; p=0.004). In addition, differences were found in eosinophil count and C-reactive protein concentrations among the three subgroups. CONCLUSIONS: In children, RDW stands out as a biomarker associated with the severity of OSA. The use of RDW and MCHC could be a simple but useful tool for the severity prediction of paediatric OSA in snoring patients. European Respiratory Society 2020-10-05 /pmc/articles/PMC7533379/ /pubmed/33043053 http://dx.doi.org/10.1183/23120541.00278-2019 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
Morell-Garcia, Daniel
Toledo-Pons, Núria
Sanchis, Pilar
Bauça, Josep Miquel
Sánchez, José María
Peña-Zarza, José
Giménez, Paloma
Pierola, Javier
de la Peña-Bravo, Mónica
Alonso-Fernández, Alberto
Barceló, Antònia
Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
title Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
title_full Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
title_fullStr Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
title_full_unstemmed Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
title_short Red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
title_sort red cell distribution width: a new tool for the severity prediction of sleep apnoea syndrome in children
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533379/
https://www.ncbi.nlm.nih.gov/pubmed/33043053
http://dx.doi.org/10.1183/23120541.00278-2019
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