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Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child

Pleuropulmonary blastoma (PPB) is a rare intrathoracic neoplasm in children. Although surgery with or without chemotherapy mainly conducted, the response of radiotherapy (RT) has not been evaluated yet. For unresectable tumor, RT might be considered as one option to decrease tumor extent to relieve...

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Autores principales: Kim, Jae Sik, Lee, Joo Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533407/
https://www.ncbi.nlm.nih.gov/pubmed/33012158
http://dx.doi.org/10.3857/roj.2020.00290
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author Kim, Jae Sik
Lee, Joo Ho
author_facet Kim, Jae Sik
Lee, Joo Ho
author_sort Kim, Jae Sik
collection PubMed
description Pleuropulmonary blastoma (PPB) is a rare intrathoracic neoplasm in children. Although surgery with or without chemotherapy mainly conducted, the response of radiotherapy (RT) has not been evaluated yet. For unresectable tumor, RT might be considered as one option to decrease tumor extent to relieve obstructing symptoms or to facilitate successive treatment. We report one child in whom PPB with DICER1 mutation recurred after surgery and lead to respiratory distress. She emergently received palliative RT with a relatively low dose (20 Gy), and symptoms sufficiently relieved. Even she showed an 84.3% reduction in diameter and maintained the remission status for 1 year. These might reflect possible radiosensitivity of PPB, and further investigations of RT might be necessary for unresectable PPB.
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spelling pubmed-75334072020-10-14 Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child Kim, Jae Sik Lee, Joo Ho Radiat Oncol J Case Report Pleuropulmonary blastoma (PPB) is a rare intrathoracic neoplasm in children. Although surgery with or without chemotherapy mainly conducted, the response of radiotherapy (RT) has not been evaluated yet. For unresectable tumor, RT might be considered as one option to decrease tumor extent to relieve obstructing symptoms or to facilitate successive treatment. We report one child in whom PPB with DICER1 mutation recurred after surgery and lead to respiratory distress. She emergently received palliative RT with a relatively low dose (20 Gy), and symptoms sufficiently relieved. Even she showed an 84.3% reduction in diameter and maintained the remission status for 1 year. These might reflect possible radiosensitivity of PPB, and further investigations of RT might be necessary for unresectable PPB. The Korean Society for Radiation Oncology 2020-06 2020-06-23 /pmc/articles/PMC7533407/ /pubmed/33012158 http://dx.doi.org/10.3857/roj.2020.00290 Text en Copyright © 2020 The Korean Society for Radiation Oncology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Jae Sik
Lee, Joo Ho
Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child
title Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child
title_full Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child
title_fullStr Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child
title_full_unstemmed Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child
title_short Exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child
title_sort exceptional response to radiotherapy in unresectable pleuropulmonary blastoma of a child
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533407/
https://www.ncbi.nlm.nih.gov/pubmed/33012158
http://dx.doi.org/10.3857/roj.2020.00290
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