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A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France

The main objective of this paper is to address the following question: are the containment measures imposed by most of the world governments effective and sufficient to stop the epidemic of COVID-19 beyond the lock-down period? In this paper, we propose a mathematical model which allows us to invest...

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Autores principales: Zongo, P., Zorom, M., Mophou, G., Dorville, R., Beaumont, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533483/
https://www.ncbi.nlm.nih.gov/pubmed/32958091
http://dx.doi.org/10.1017/S0950268820002162
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author Zongo, P.
Zorom, M.
Mophou, G.
Dorville, R.
Beaumont, C.
author_facet Zongo, P.
Zorom, M.
Mophou, G.
Dorville, R.
Beaumont, C.
author_sort Zongo, P.
collection PubMed
description The main objective of this paper is to address the following question: are the containment measures imposed by most of the world governments effective and sufficient to stop the epidemic of COVID-19 beyond the lock-down period? In this paper, we propose a mathematical model which allows us to investigate and analyse this problem. We show by means of the reproductive number, [Image: see text] that the containment measures appear to have slowed the growth of the outbreak. Nevertheless, these measures remain only effective as long as a very large fraction of population, p, greater than the critical value [Image: see text] remains confined. Using French current data, we give some simulation experiments with five scenarios including: (i) the validation of model with p estimated to 93%, (ii) the study of the effectiveness of containment measures, (iii) the study of the effectiveness of the large-scale testing, (iv) the study of the social distancing and wearing masks measures and (v) the study taking into account the combination of the large-scale test of detection of infected individuals and the social distancing with linear progressive easing of restrictions. The latter scenario was shown to be effective at overcoming the outbreak if the transmission rate decreases to 75% and the number of tests of detection is multiplied by three. We also noticed that if the measures studied in our five scenarios are taken separately then the second wave might occur at least as far as the parameter values remain unchanged.
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spelling pubmed-75334832020-10-05 A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France Zongo, P. Zorom, M. Mophou, G. Dorville, R. Beaumont, C. Epidemiol Infect Original Paper The main objective of this paper is to address the following question: are the containment measures imposed by most of the world governments effective and sufficient to stop the epidemic of COVID-19 beyond the lock-down period? In this paper, we propose a mathematical model which allows us to investigate and analyse this problem. We show by means of the reproductive number, [Image: see text] that the containment measures appear to have slowed the growth of the outbreak. Nevertheless, these measures remain only effective as long as a very large fraction of population, p, greater than the critical value [Image: see text] remains confined. Using French current data, we give some simulation experiments with five scenarios including: (i) the validation of model with p estimated to 93%, (ii) the study of the effectiveness of containment measures, (iii) the study of the effectiveness of the large-scale testing, (iv) the study of the social distancing and wearing masks measures and (v) the study taking into account the combination of the large-scale test of detection of infected individuals and the social distancing with linear progressive easing of restrictions. The latter scenario was shown to be effective at overcoming the outbreak if the transmission rate decreases to 75% and the number of tests of detection is multiplied by three. We also noticed that if the measures studied in our five scenarios are taken separately then the second wave might occur at least as far as the parameter values remain unchanged. Cambridge University Press 2020-09-22 /pmc/articles/PMC7533483/ /pubmed/32958091 http://dx.doi.org/10.1017/S0950268820002162 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Zongo, P.
Zorom, M.
Mophou, G.
Dorville, R.
Beaumont, C.
A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France
title A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France
title_full A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France
title_fullStr A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France
title_full_unstemmed A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France
title_short A model of COVID-19 transmission to understand the effectiveness of the containment measures: application to data from France
title_sort model of covid-19 transmission to understand the effectiveness of the containment measures: application to data from france
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533483/
https://www.ncbi.nlm.nih.gov/pubmed/32958091
http://dx.doi.org/10.1017/S0950268820002162
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